Loss of muscle proteins is a deleterious consequence of chronic kidney disease (CKD) that
causes a decrease in muscle strength and function, and can lead to a reduction in quality of …

In patients with chronic kidney disease (CKD), loss of cellular proteins increases the risks of
morbidity and mortality. Persistence of muscle protein catabolism in CKD results in striking …

All intracellular proteins and many extracellular proteins are continually “turning over;” ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis …

Skeletal muscle atrophy is a debilitating response to starvation and many systemic diseases
including diabetes, cancer, and renal failure. We had proposed that a common set of …

All proteins in mammalian cells are continually being degraded and replaced. In the cytosol,
nucleus, and organelles, individual proteins are degraded at widely differing rates; some …

All intracellular proteins and many extracellular proteins are continually “turning over”; ie,
they are being hydrolyzed to their constituent amino acids and replaced by new synthesis …

Conditions such as acidosis, uremia, and sepsis are characterized by insulin resistance and
muscle wasting, but whether the insulin resistance associated with these disorders …

Muscle atrophy results primarily from accelerated protein degradation and is associated with
increased expression of two muscle-specific ubiquitin ligases (E3s): atrogin-1 and muscle …

Rising interest in the mechanism and function of the proteasomes and the ubiquitin system
revealed that it is hard to find any aspect of the cellular metabolic network that is not directly …

Muscle wasting (or sarcopenia) is a common feature of the uremic phenotype and
predisposes this vulnerable patient population to increased risk of comorbid complications …