The hallmark of tumorigenesis is the successful circumvention of cell death regulation for
achieving unlimited replication and immortality. Ferroptosis is a newly identified type of cell …

The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate
immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase …

Copper is an essential cofactor for all organisms, and yet it becomes toxic if concentrations
exceed a threshold maintained by evolutionarily conserved homeostatic mechanisms. How …

Currently, pyroptosis has received more and more attention because of its association with
innate immunity and disease. The research scope of pyroptosis has expanded with the …

The cell-autonomous innate immune system enables animal cells to resist viral infection.
This system comprises an array of sensors that, after detecting viral molecules, activate the …

Pyroptosis is a gasdermin-mediated programmed necrosis that occurs via membrane
perforation and that can be exploited for biomedical applications in cancer therapy …

Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing
attention as a promising approach to cancer immunotherapy. However, biocompatible …

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

In recent decades, chemotherapies targeting apoptosis have emerged and demonstrated
remarkable achievements. However, emerging evidence has shown that chemoresistance is …

Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of
inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the …