Ferroptosis and cancer: mitochondria meet the “iron maiden” cell death

AM Battaglia, R Chirillo, I Aversa, A Sacco, F Costanzo… - Cells, 2020 - mdpi.com
Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent
lipid peroxidation. As major sites of iron utilization and master regulators of oxidative …

Oxidative stress, inflammation, and vascular aging in hypertension

TJ Guzik, RM Touyz - Hypertension, 2017 - Am Heart Assoc
Guzik and Touyz Oxidation and Inflammation in Vascular Aging 661 and endothelium. 22
Perivascular fibrosis is greatly dependent on immune cells because it is prevented in …

Ferroptosis, a new form of cell death: opportunities and challenges in cancer

Y Mou, J Wang, J Wu, D He, C Zhang, C Duan… - Journal of hematology & …, 2019 - Springer
Ferroptosis is a novel type of cell death with distinct properties and recognizing functions
involved in physical conditions or various diseases including cancers. The fast-growing …

Regulatory pathways and drugs associated with ferroptosis in tumors

D Wang, L Tang, Y Zhang, G Ge, X Jiang, Y Mo… - Cell Death & …, 2022 - nature.com
Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS).
The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane …

Abnormal calcium handling in Duchenne muscular dystrophy: mechanisms and potential therapies

S Mareedu, ED Million, D Duan, GJ Babu - Frontiers in physiology, 2021 - frontiersin.org
Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …

MicroRNA and ROS crosstalk in cardiac and pulmonary diseases

M Climent, G Viggiani, YW Chen, G Coulis… - International Journal of …, 2020 - mdpi.com
Reactive oxygen species (ROS) affect many cellular functions and the proper redox balance
between ROS and antioxidants contributes substantially to the physiological welfare of the …

The relationship between ferroptosis and tumors: a novel landscape for therapeutic approach

X Xia, X Fan, M Zhao, P Zhu - Current gene therapy, 2019 - ingentaconnect.com
Background: Ferroptosis is a newly discovered form of iron-dependent oxidative cell death
characterized by lethal accumulation of lipid-based reactive oxygen species (ROS). It is …

[HTML][HTML] Focus: the science of stress: oxidative stress and inflammation in cardiovascular diseases and cancer: role of non-coding RNAs

P Ginckels, P Holvoet - The Yale Journal of Biology and Medicine, 2022 - ncbi.nlm.nih.gov
Abstract High oxidative stress, Th1/Th17 immune response, M1 macrophage inflammation,
and cell death are associated with cardiovascular diseases. Controlled oxidative stress …

MicroRNAs and obesity-induced endothelial dysfunction: key paradigms in molecular therapy

K Ait-Aissa, QM Nguyen, M Gabani, A Kassan… - Cardiovascular …, 2020 - Springer
The endothelium plays a pivotal role in maintaining vascular health. Obesity is a global
epidemic that has seen dramatic increases in both adult and pediatric populations. Obesity …

[HTML][HTML] AGE/RAGE signaling-mediated endoplasmic reticulum stress and future prospects in non-coding RNA therapeutics for diabetic nephropathy

N Pathomthongtaweechai… - Biomedicine & …, 2020 - Elsevier
Disturbance of endoplasmic reticulum (ER) homeostasis triggered by the accumulation of
unfolded proteins and advanced glycation end-products (AGEs) plays a major role in …