Sepsis is triggered by microbial infection, injury, or even major surgery. Both innate and
adaptive immune systems are involved in its pathogenesis. Cytoplasmic presence of DNA or …

Micronuclei (MN), the small nucleus-like bodies separated from the primary nucleus, can
exist in cells with numerical and/or structural chromosomal aberrations in apparently normal …

Micronuclei are constantly considered as a marker of genome instability and very recently
found to be a trigger of innate immune responses. An increased frequency of micronuclei is …

The micronucleus assay in uncultured exfoliated buccal mucosa cells, involving minimally
invasive sampling, was successfully applied to evaluate inhalation and local exposure to …

Autoimmune diseases are driven by TH17 cells that secrete pro-inflammatory cytokines,
especially IL-17. Under normal physiological conditions, autoreactive T cells are suppressed …

The lifespan of humans has increased drastically over the last decades; considerable effort
has been applied to delineate the mechanisms behind aging in order to find strategies for …

Autoimmune diseases (AD) are classified into organ‐specific, systemic, and mixed; all forms
of AD share a high risk for cancer development. In AD a destructive immune response …

Scleritis and other autoimmune diseases are characterized by an imbalance in the levels of
pro-inflammatory and anti-inflammatory molecules with the balance tilted more towards the …

Increased DNA damage has been suggested to contribute to the pathogenesis of chronic
inflammatory diseases, but controlled studies are lacking in ankylosing spondylitis (AS) …

Patients with end-stage renal disease (ESRD) require hemodialysis. However, dialysis
therapy may cause genomic damage due to increased oxidative stress. Non-invasive …