Crystal engineering of pharmaceutical cocrystals in the discovery and development of improved drugs
The subject of crystal engineering started in the 1970s with the study of topochemical
reactions in the solid state. A broad chemical definition of crystal engineering was published …
reactions in the solid state. A broad chemical definition of crystal engineering was published …
Pharmaceutical cocrystals: New solid phase modification approaches for the formulation of APIs
Cocrystals can be used as an alternative approach based on crystal engineering to enhance
specific physicochemical and biopharmaceutical properties of active pharmaceutical …
specific physicochemical and biopharmaceutical properties of active pharmaceutical …
Crystal engineering: from molecule to crystal
GR Desiraju - Journal of the American Chemical Society, 2013 - ACS Publications
How do molecules aggregate in solution, and how do these aggregates consolidate
themselves in crystals? What is the relationship between the structure of a molecule and the …
themselves in crystals? What is the relationship between the structure of a molecule and the …
Multidrug co-crystals: towards the development of effective therapeutic hybrids
Highlights•Multi-drug co-crystals would offer an efficient solution to combat various
diseases.•Cocrystals would play vital role in market due to expanded patent …
diseases.•Cocrystals would play vital role in market due to expanded patent …
An overview of recent studies on the analysis of pharmaceutical polymorphs
Pharmaceutical solids are well known to be able to exist in different solid-state forms and
there are a wide variety of solid-state analytical techniques available to characterize …
there are a wide variety of solid-state analytical techniques available to characterize …
[HTML][HTML] Drug-drug cocrystals: Opportunities and challenges
X Wang, S Du, R Zhang, X Jia, T Yang… - Asian journal of …, 2021 - Elsevier
Recently, drug-drug cocrystal attracts more and more attention. It offers a low risk, low-cost
but high reward route to new and better medicines and could improve the physiochemical …
but high reward route to new and better medicines and could improve the physiochemical …
[PDF][PDF] Pharmaceutical Cocrystals: An Overview.
Poor aqueous solubility and low oral bioavailability of an active pharmaceutical ingredient
are the major constraints during the development of new product. Various approaches have …
are the major constraints during the development of new product. Various approaches have …
Drug-drug and drug-nutraceutical cocrystal/salt as alternative medicine for combination therapy: a crystal engineering approach
R Thakuria, B Sarma - Crystals, 2018 - mdpi.com
The pre-formulation of pharmaceutical cocrystals and salts is a concept of crystal
engineering that has emerged as a promising technique for drug development in …
engineering that has emerged as a promising technique for drug development in …
Fast dissolving curcumin cocrystals
Curcumin is the principal curcuminoid of the popular Indian spice turmeric. Despite the
diverse pharmacological activities of this bioactive phenol, its application as a drug is …
diverse pharmacological activities of this bioactive phenol, its application as a drug is …
Cocrystals by design: a rational coformer selection approach for tackling the API problems
Active pharmaceutical ingredients (API) with unfavorable physicochemical properties and
stability present a significant challenge during their processing into final dosage forms …
stability present a significant challenge during their processing into final dosage forms …