Chalcone hybrids as potential anticancer agents: Current development, mechanism of action, and structure‐activity relationship

F Gao, G Huang, J Xiao - Medicinal research reviews, 2020 - Wiley Online Library
The continuous emergency of drug‐resistant cancers and the low specificity of anticancer
agents have been the major challenges in the control and treatment of cancer, making an …

Antibacterial potential of chalcones and its derivatives against Staphylococcus aureus

L da Silva, IA Donato, CAC Gonçalves, JR Scherf… - 3 Biotech, 2023 - Springer
Chalcones are natural substances found in the metabolism of several botanical families.
Their structure consists of 1, 3-diphenyl-2-propen-1-one and they are characterized by …

Ramachary-Bressy-Wang [3+ 2] cycloaddition reaction: Synthesis of fully decorated 1, 2, 3-triazoles as potent anticancer and EGFR inhibitors

M Kumar, SK Nukala, NS Thirukovela… - Journal of Molecular …, 2022 - Elsevier
A general strategy was developed for the synthesis of new fully decorated 1, 2, 3-triazoles
(5a-m & 6a-e) containing coumarine and sulfonyl-benzimidazole from 3-(2-((1-methyl-1H …

First synthesis of merged hybrids phosphorylated azirino [2, 1-b] benzo [e][1, 3] oxazine derivatives as anticancer agents

V Carraminana, AMO de Retana… - European Journal of …, 2020 - Elsevier
This work describes a straightforward diastereoselective synthetic access to azirino [2, 1-b]
benzo [e][1, 3] oxazines containing phosphorus substituents such as phosphonate or …

Design, Synthesis, In Vitro Evaluation and Docking Studies of Pyrazole‐Thiazole Hybrids as Antimicrobial and Antibiofilm Agents

R Gondru, K Sirisha, S Raj, SK Gunda… - …, 2018 - Wiley Online Library
In the present study, a series of novel pyrazole‐thiazole hybrids (4a‐l) were designed,
synthesized and assessed for their in vitro antimicrobial activity against both Gram‐positive …

Synthesis and biological evaluation of cyanoaziridine phosphine oxides and phosphonates with antiproliferative activity

V Carramiñana, AMO de Retana, AV Del Burgo… - European Journal of …, 2019 - Elsevier
This work reports an efficient diastereoselective synthetic methodology for the preparation of
phosphorus substituted cyanoaziridines through the nucleophilic addition of TMSCN, as …

3′, 4′, 5′-trimethoxy-and 3, 4-dimethoxychalcones targeting A549 cells: Synthesis, cytotoxic activity, and molecular docking

A Danova, DV Nguyen, R Toyoda… - Journal of Molecular …, 2023 - Elsevier
Cancer is responsible for death in the world [1]. According to GLOBOCAN 2018, lung cancer
is the most observed cancer, including 11.6% of 18.1 million new cancer cases and 18.4 …

[HTML][HTML] Synthesis of α-Aminophosphonic Acid Derivatives Through the Addition of O- and S-Nucleophiles to 2H-Azirines and Their Antiproliferative Effect on A549 …

V Carramiñana, AM Ochoa de Retana, F Palacios… - Molecules, 2020 - mdpi.com
This work reports a straightforward regioselective synthetic methodology to prepare α-
aminophosphine oxides and phosphonates through the addition of oxygen and sulfur …

Recent advances in chalcone-based anticancer heterocycles: A structural and molecular target perspective

V Kumar, S Dhawan, PS Girase… - Current Medicinal …, 2021 - ingentaconnect.com
Chalcones are an interesting class of compounds endowed with a plethora of biological
activities beneficial to human health. These chemotypes have continued to attract increased …

Synthesis, Spectroscopic Characterization, DFT Analysis, Antibacterial, Antifungal, Antioxidant, Molecular docking, and ADME study of 3, 4-dihydro-2H-napthalen-1 …

RA Shinde, VA Adole, RA More, BS Jagdale… - Journal of Molecular …, 2024 - Elsevier
Chalcone derivatives were synthesized from 3, 4-dihydro-2H-naphthalen-1-one using a
base-catalyzed Claisen-Schmidt reaction and characterized by FT-IR, ¹H NMR, and ¹³C …