Since its discovery in 1975, TNFα has been a subject of intense study as it plays significant
roles in both immunity and cancer. Such attention is well deserved as TNFα is unique in its …

Macrophages stand in the first line of defense against a variety of pathogens but are also
involved in the maintenance of tissue homeostasis. To fulfill their functions macrophages …

Alternative splicing (AS) is a complex coordinated transcriptional regulatory mechanism. It
affects nearly 95% of all protein-coding genes and occurs in nearly all human organs …

Alternative splicing affects more than 95% of multi-exon genes in the human genome. These
changes affect the proteome in a myriad of ways. Here, we review our understanding of the …

This review analyzes the role of TNF-α and its increase in biological fluids in mild cognitive
impairment, and Alzheimer's disease (AD). The potential inhibition of TNF-α with …

Alternative splicing is now commonly thought to affect more than half of all human genes.
Recent studies have investigated not only the scope but also the biological impact of …

Tumor necrosis factor alpha (TNFα), a pleiotropic cytokine, plays important inflammatory
roles in renal diseases such as lupus nephritis, anti-neutrophil cytoplasmic antibody (ANCA) …

Soluble cytokine receptors play key roles in regulating cytokine-mediated biological events
by binding and modulating the activity of target ligands in either an antagonistic or agonistic …

Alternative splicing is a key process of multi-exonic gene expression during pre-mRNA
maturation. In this process, particular exons of a gene will be included within or excluded …

High Tumor Necrosis Factor Receptor 2 (TNFR2) expression is characteristic of diverse
malignant cells during tumorigenesis. The protein is also expressed by many …