Rational use of antibiotic is the key approach to improve the antibiotic performance and
tackling of the antimicrobial resistance. The efficacy of antimicrobials are influenced by many …

The increasing prevalence of hospital and community-acquired infections caused by
multidrug-resistant (MDR) bacterial pathogens is limiting the options for effective antibiotic …

Fosfomycin is a bactericidal, low-molecular weight, broad-spectrum antibiotic, with putative
activity against several bacteria, including multidrug-resistant Gram-negative bacteria, by …

Pharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an
important tool for rational drug development and drug use, where developed models …

Within a susceptible wild-type population, a small fraction of cells, even< 10− 9, is not
affected when challenged by an antimicrobial agent. This subpopulation has mutations that …

Recent advances in lab-on-a-chip technology establish solid foundations for wearable
biosensors. These newly emerging wearable biosensors are capable of non-invasive …

Periprosthetic infection (PI) causes significant morbidity and mortality after fixation and joint
arthroplasty and has been extensively linked to the formation of bacterial biofilms. Poly …

Clinical breakpoints are used in clinical microbiology laboratories to categorize
microorganisms as clinically susceptible (S), intermediate (I) or resistant (R) dependent on …

Because of increasing antimicrobial resistance and the shortage of new antibiotics, there is
a growing need to optimize the use of old and new antibiotics. Modelling of the …

Co-resistance involves transfer of several genes into the same bacteria and/or the
acquisition of mutations in different genetic loci affecting different antimicrobials whereas …