[HTML][HTML] The molecular athlete: exercise physiology from mechanisms to medals

R Furrer, JA Hawley, C Handschin - Physiological Reviews, 2023 - journals.physiology.org
Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Mapping genes for complex traits in domestic animals and their use in breeding programmes

ME Goddard, BJ Hayes - Nature Reviews Genetics, 2009 - nature.com
Genome-wide panels of SNPs have recently been used in domestic animal species to map
and identify genes for many traits and to select genetically desirable livestock. This has led …

The myostatin gene: an overview of mechanisms of action and its relevance to livestock animals

D Aiello, K Patel, E Lasagna - Animal genetics, 2018 - Wiley Online Library
Myostatin, also known as growth differentiation factor 8, a member of the transforming
growth factor‐beta super‐family, is a negative regulator of muscle development. Myostatin …

Is genetic evolution predictable?

DL Stern, V Orgogozo - Science, 2009 - science.org
Ever since the integration of Mendelian genetics into evolutionary biology in the early 20th
century, evolutionary geneticists have for the most part treated genes and mutations as …

Genetic and environmental effects on meat quality

RD Warner, PL Greenwood, DW Pethick, DM Ferguson - Meat science, 2010 - Elsevier
In order for livestock industries to consistently produce high quality meat, there must be an
understanding of the factors that cause quality to vary, as well as the contribution of genetics …

Efficient generation of myostatin mutations in pigs using the CRISPR/Cas9 system

K Wang, H Ouyang, Z Xie, C Yao, N Guo, M Li, H Jiao… - Scientific reports, 2015 - nature.com
Genetically modified pigs are increasingly used for biomedical and agricultural applications.
The efficient CRISPR/Cas9 gene editing system holds great promise for the generation of …

Targeted mutations in myostatin by zinc-finger nucleases result in double-muscled phenotype in Meishan pigs

L Qian, M Tang, J Yang, Q Wang, C Cai, S Jiang, H Li… - Scientific reports, 2015 - nature.com
Myostatin (MSTN) is a dominant inhibitor of skeletal muscle development and growth.
Mutations in MSTN gene can lead to muscle hypertrophy or double-muscled (DM) …

Differentiation plasticity regulated by TGF-β family proteins in development and disease

R Derynck, RJ Akhurst - Nature cell biology, 2007 - nature.com
During development, stem and progenitor cells gradually commit to differentiation pathways.
Cell fate decisions are regulated by differentiation factors, which activate transcription …

[HTML][HTML] On-farm and processing factors affecting bovine carcass and meat quality

A Clinquart, MP Ellies-Oury, JF Hocquette, L Guillier… - Animal, 2022 - Elsevier
This paper reviews the current state of knowledge on beef carcass and meat quality, with
particular emphasis on on-farm and processing factors associated with its high and …

Large-effect pleiotropic or closely linked QTL segregate within and across ten US cattle breeds

M Saatchi, RD Schnabel, JF Taylor, DJ Garrick - BMC genomics, 2014 - Springer
Background The availability of high-density SNP assays including the BovineSNP50 (50 K)
enables the identification of novel quantitative trait loci (QTL) and improvement of the …