Wnt signaling has multiple functions beyond the transcriptional effects of β-catenin
stabilization. We review recent investigations that uncover new cell physiological effects …

Altered expression of secreted factors by tumor cells or cells of the tumor microenvironment
is a key event in cancer development and progression. In the last decade, emerging …

The intestinal epithelium is a structured organ composed of crypts harboring Lgr5+ stem
cells, and villi harboring differentiated cells. Spatial transcriptomics have demonstrated …

The spatial organization of the tumor microenvironment has a profound impact on biology
and therapy response. Here, we perform an integrative single-cell and spatial transcriptomic …

Further determination of ANGPTL4 regulatory circuits and defining specific molecular events
that mediate its biological effects remain key to future ANGPTL4-based therapeutic …

Wnt/β‐catenin signaling is an ancient pathway that regulates key aspects of embryonic
development, cell differentiation, proliferation, and adult stem cell homeostasis. Work from …

Primary tumors and distant site metastases form a bidirectionally communicating system.
Yet, the molecular mechanisms of this crosstalk are poorly understood. Here, we identified …

Abstract Background: Angiopoietin-like 4 (ANGPTL4) belongs to the angiopoietin-like
protein family and mediates the inhibition of lipoprotein lipase activity. Emerging evidence …

Wnt signaling plays crucial roles in development and tissue homeostasis, and its
dysregulation leads to various diseases, notably cancer. Wnt/β-catenin signaling is initiated …

WNT signaling is important in development, stem cell maintenance, and disease. WNT
ligands typically signal via receptor activation across the plasma membrane to induce β …