Short chain fatty acids: microbial metabolites for gut-brain axis signalling

KJ O'Riordan, MK Collins, GM Moloney… - Molecular and Cellular …, 2022 - Elsevier
The role of the intestinal microbiota as a regulator of gut-brain axis signalling has risen to
prominence in recent years. Understanding the relationship between the gut microbiota, the …

Short chain fatty acids: key regulators of the local and systemic immune response in inflammatory diseases and infections

LM Ney, M Wipplinger, M Grossmann… - Open …, 2023 - royalsocietypublishing.org
The human intestinal microbiome substantially affects human health and resistance to
infections in its dynamic composition and varying release of microbial-derived metabolites …

[PDF][PDF] Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells

L Dupraz, A Magniez, N Rolhion, ML Richard… - Cell Reports, 2021 - cell.com
Summary Gut interleukin-17A (IL-17)-producing γδ T cells are tissue-resident cells that are
involved in both host defense and regulation of intestinal inflammation. However, factors that …

Lung immune tone via gut-lung axis: Gut-derived LPS and short-chain fatty acids' immunometabolic regulation of lung IL-1β, FFAR2, and FFAR3 expression

Q Liu, X Tian, D Maruyama… - American Journal of …, 2021 - journals.physiology.org
Microbial metabolites produced by the gut microbiome, eg short-chain fatty acids (SCFA),
have been found to influence lung physiology and injury responses. However, how lung …

[HTML][HTML] Short chain fatty acids, a possible treatment option for autoimmune diseases

F Golpour, M Abbasi-Alaei, F Babaei… - Biomedicine & …, 2023 - Elsevier
Gut microbiota can interact with the immune system through its metabolites. Short-chain fatty
acids (SCFAs), as one of the most abundant metabolites of the resident gut microbiota play …

[HTML][HTML] Gut microbiota dysbiosis correlates with long COVID-19 at one-year after discharge

D Zhang, Y Zhou, Y Ma, P Chen, J Tang… - Journal of Korean …, 2023 - ncbi.nlm.nih.gov
Background Long coronavirus disease 2019 (COVID-19) in recovered patients (RPs) is
gradually recognized by more people. However, how long it will last and the underlining …

[HTML][HTML] Immunomodulatory roles of microbiota-derived short-chain fatty acids in bacterial infections

R Ranjbar, SN Vahdati, S Tavakoli, R Khodaie… - Biomedicine & …, 2021 - Elsevier
In recent years, an overwhelming amount of evidence has positively recommended a
significant role of microbiota in human health and disease. Microbiota also plays a crucial …

Short-chain fatty acids as a potential treatment for infections: a closer look at the lungs

MG Machado, V Sencio, F Trottein - Infection and immunity, 2021 - Am Soc Microbiol
Short-chain fatty acids (SCFAs) are the main metabolites produced by the gut microbiota via
the fermentation of complex carbohydrates and fibers. Evidence suggests that SCFAs play a …

The gut microbiome-joint connection: implications in osteoarthritis

LJ Favazzo, H Hendesi, DA Villani… - Current opinion in …, 2020 - journals.lww.com
Although role of the microbiome in osteoarthritis is an area of intense study, no clear
mechanism of action has been determined. Increased understanding of how the two factors …

[HTML][HTML] The gut-lung axis in severe acute Pancreatitis-associated lung injury: The protection by the gut microbiota through short-chain fatty acids

Z Wang, J Liu, F Li, Y Luo, P Ge, Y Zhang… - Pharmacological …, 2022 - Elsevier
The role of gut microbiota in regulating the intestinal homeostasis, as well as the
pathogenesis of severe acute pancreatitis-associated lung injury (PALI) is widely …