Interleukin-6 signaling and anti-interleukin-6 therapeutics in cardiovascular disease

PM Ridker, M Rane - Circulation research, 2021 - Am Heart Assoc
IL (interleukin)-6 is a pivotal cytokine of innate immunity, which enacts a broad set of
physiological functions traditionally associated with host defense, immune cell regulation …

From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection

PM Ridker - Circulation research, 2016 - Am Heart Assoc
Plasma levels of the inflammatory biomarker high-sensitivity C-reactive protein (hsCRP)
predict vascular risk with an effect estimate as large as that of total or high-density …

A test in context: high-sensitivity C-reactive protein

PM Ridker - Journal of the American College of Cardiology, 2016 - jacc.org
The inflammatory biomarker high-sensitivity C-reactive protein (hsCRP) adds prognostic
information on cardiovascular risk comparable to blood pressure or cholesterol. Values< 1, 1 …

[HTML][HTML] Novel biomarkers for cardiovascular risk prediction

J Wang, GJ Tan, LN Han, YY Bai, M He… - Journal of geriatric …, 2017 - ncbi.nlm.nih.gov
Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. The
primary prevention of CVD is dependent upon the ability to identify high-risk individuals long …

C-reactive protein: a target for therapy to reduce inflammation

SA Rizo-Téllez, M Sekheri, JG Filep - Frontiers in immunology, 2023 - frontiersin.org
C-reactive protein (CRP) is well-recognized as a sensitive biomarker of inflammation.
Association of elevations in plasma/serum CRP level with disease state has received …

C-reactive protein and inflammation: conformational changes affect function

Y Wu, LA Potempa, D El Kebir, JG Filep - Biological chemistry, 2015 - degruyter.com
The prototypic acute-phase reactant C-reactive protein (CRP) has long been recognized as
a useful marker and gauge of inflammation. CRP also plays an important role in host …

C-reactive protein, immunothrombosis and venous thromboembolism

C Dix, J Zeller, H Stevens, SU Eisenhardt… - Frontiers in …, 2022 - frontiersin.org
C-reactive protein (CRP) is a member of the highly conserved pentraxin superfamily of
proteins and is often used in clinical practice as a marker of infection and inflammation …

Targeting residual inflammatory risk: a shifting paradigm for atherosclerotic disease

AW Aday, PM Ridker - Frontiers in cardiovascular medicine, 2019 - frontiersin.org
As biologic, epidemiologic, and clinical trial data have demonstrated, inflammation is a key
driver of atherosclerosis. Circulating biomarkers of inflammation, including high-sensitivity C …

Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites

D Braig, TL Nero, HG Koch, B Kaiser, X Wang… - Nature …, 2017 - nature.com
C-reactive protein (CRP) concentrations rise in response to tissue injury or infection.
Circulating pentameric CRP (pCRP) localizes to damaged tissue where it leads to …

Clinician's Guide to Reducing Inflammation to Reduce Atherothrombotic Risk: JACC Review Topic of the Week

PM Ridker - Journal of the American College of Cardiology, 2018 - jacc.org
Life-threatening cardiovascular events occur despite control of conventional risk factors.
Inflammation, as measured by high-sensitivity C-reactive protein (hsCRP) concentration, is …