The scientific landscape surrounding amyotrophic lateral sclerosis (ALS) continues to shift
as the number of genes associated with the disease risk and pathogenesis, and the cellular …

Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure
leading to mortality. The main locus of ALS is motor neurons. The success of antisense …

Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease, characterized
genetically by a disproportionately large contribution of rare genetic variation. Driven by …

Simulation is a key tool in population genetics for both methods development and empirical
research, but producing simulations that recapitulate the main features of genomic datasets …

Amyotrophic lateral sclerosis (ALS) is the third most common adult onset neurodegenerative
disorder worldwide. It is generally characterized by progressive paralysis starting at the …

Advances achieved with molecular biology and genomics technologies have permitted
investigators to discover epigenetic mechanisms, such as DNA methylation and histone …

The neuropharmacological community has shown a strong interest in AMPA receptors as
critical components of excitatory synaptic transmission during the last fifteen years. AMPA …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with no known
cure. Approximately 90% of ALS cases are sporadic, although multiple genetic risk factors …

Abstract Charcot-Marie-Tooth (CMT) neuropathies are amongst the most common inherited
diseases in neurology. While great strides have been made to identify the genesis of these …

Abstract Introduction Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease
with an elusive etiology. While environmental factors have been considered, familial ALS …