Gene therapy has gained significant attention over the past two decades as a potential
method for treating genetic disorders such as severe combined immunodeficiency, 1 cystic …

The Michael addition reaction is a versatile synthetic methodology for the efficient coupling
of electron poor olefins with a vast array of nucleophiles. This review outlines the role of the …

Dendrimers are highly branched macromolecules of low polydispersity that provide many
exciting opportunities for design of novel drug-carriers, gene delivery systems and imaging …

Cancer remains a major killer of mankind. Failure of conventional chemotherapy has
resulted in recurrence and development of virulent multi drug resistant (MDR) phenotypes …

Liposomes are being increasingly utilized to deliver drugs, enzymes, antisense
oligonucleotides, and genes to various therapeutic targets. Liposome-mediated delivery of …

In this study, we have designed, synthesized and characterized a novel pH-responsive
polymeric carrier for the enhanced cytoplasmic delivery of enzyme susceptible drugs, such …

Many macromolecular therapeutics such as peptides, proteins, antisense
oligodeoxynucleotides (ASODN), and short interfering RNA (siRNA) are active only in the …

The biotechnology and pharmaceutical industries have developed a wide variety of potential
therapeutics based on the molecules of biology: DNA, RNA, and proteins. While these …

Abstract Poly (amido‐amine) s (PAAs) are synthetic tert‐amino polymers obtained by
stepwise polyaddition of primary or secondary aliphatic amines to bis (acrylamide) s. Linear …

The delivery of biomolecular therapeutics that function intracellularly remains a significant
challenge in the field of biotechnology. In this report, a new family of polymeric drug carriers …