Understanding microglial responses in large animal models of traumatic brain injury: an underutilized resource for preclinical and translational research

MR Grovola, C von Reyn, DJ Loane… - Journal of …, 2023 - Springer
Traumatic brain injury (TBI) often results in prolonged or permanent brain dysfunction with
over 2.8 million affected annually in the US, including over 56,000 deaths, with over 5 million …

Targets of neuroprotection and review of pharmacological interventions in traumatic brain injury

MI Hiskens - Journal of Pharmacology and Experimental …, 2022 - ASPET
Traumatic brain injury (TBI) is a major contributor to disability and death worldwide, and
manifests in cognitive, behavioral, and motor impairment. Although there have been …

Repetitive mild traumatic brain injury-induced neurodegeneration and inflammation is attenuated by acetyl-L-carnitine in a preclinical model

MI Hiskens, KM Li, AG Schneiders… - Frontiers in …, 2023 - frontiersin.org
Repetitive mild traumatic brain injuries (rmTBI) may contribute to the development of
neurodegenerative diseases through secondary injury pathways. Acetyl-L-carnitine (ALC) …

Loss of consciousness and righting reflex following traumatic brain injury: predictors of post-injury symptom development (a narrative review)

R Berman, H Spencer, M Boese, S Kim, K Radford… - Brain sciences, 2023 - mdpi.com
Identifying predictors for individuals vulnerable to the adverse effects of traumatic brain
injury (TBI) remains an ongoing research pursuit. This is especially important for patients …

Mitoquinone supplementation alleviates oxidative stress and pathologic outcomes following repetitive mild traumatic brain injury at a chronic time point

M Tabet, M El-Kurdi, MA Haidar, L Nasrallah… - Experimental …, 2022 - Elsevier
Traumatic brain injury (TBI) is a major cause of disability and death. Mild TBI (mTBI)
constitutes~ 75% of all TBI cases. Repeated exposure to mTBI (rmTBI), leads to the …

Cognitive impairment in Chinese traumatic brain injury patients: from challenge to future perspectives

T Liu, S Yu, M Liu, Z Zhao, J Yuan, Z Sha… - Frontiers in …, 2024 - frontiersin.org
Traumatic Brain Injury (TBI) is a prevalent form of neurological damage that may induce
varying degrees of cognitive dysfunction in patients, consequently impacting their quality of …

Unraveling the toxic effects mediated by the neurodegenerative disease–associated S375G mutation of TDP-43 and its S375E phosphomimetic variant

F Paron, S Barattucci, S Cappelli, M Romano… - Journal of Biological …, 2022 - ASBMB
TAR DNA-binding protein 43 (TDP-43) is a nucleic acid–binding protein found in the
nucleus that accumulates in the cytoplasm under pathological conditions, leading to …

Partial depletion of microglia attenuates long-term potentiation deficits following repeated blast traumatic brain injury in organotypic hippocampal slice cultures

N Varghese, B Morrison III - Journal of Neurotrauma, 2023 - liebertpub.com
Blast-induced traumatic brain injury (bTBI) has been a health concern in both military and
civilian populations due to recent military and geopolitical conflicts. Military service members …

Regulation of microglial responses after pediatric traumatic brain injury: exploring the role of SHIP-1

E Chu, R Mychasiuk, TRF Green, A Zamani… - Frontiers in …, 2023 - frontiersin.org
Introduction Severe traumatic brain injury (TBI) is the world's leading cause of permanent
neurological disability in children. TBI-induced neurological deficits may be driven by …

Neuroprotective Effect of Sub-lethal Hyperthermia Preconditioning in a Rat Model of Repeated Closed Head Injury

J Xiong, Y Lv, X Ma, G Peng, C Wu, J Hou, Y Zhang… - Neuroscience, 2023 - Elsevier
Repeated mild traumatic brain injury (rTBI), one of the most common forms of traumatic brain
injury, is a worldwide severe public health concern. rTBI induces cumulative neuronal injury …