Podosomes and invadopodia, collectively known as invadosomes, are cell-matrix contacts
in a variety of cell types, such as monocytic cells or cancer cells, that have to cross tissue …

Podosomes are highly dynamic, actin-rich adhesion structures of monocyte-derived cells,
certain transformed fibroblasts and carcinoma cells and have recently also been discovered …

The actin cytoskeleton is essential for osteoclasts main function, bone resorption. Two
different organizations of actin have been described in osteoclasts, the podosomes belt …

Podosomes in a primary macrophage (left) and invadopodia in a melanoma cell (right). Note
the two-part architecture of podosomes, which have a core structure (stained for F-actin …

Podosomes are actin-rich adhesion and invasion structures. Especially in macrophages,
podosomes exist in two subpopulations, large precursors at the cell periphery and smaller …

Although bone is one of the hardest tissues in the body, necessary for its structural and
protective roles, this organ is not static. Bone matrix must be renewed over time in order to …

Osteoclast differentiation is critically dependent on calcium (Ca2+) signaling. Transient
receptor potential vanilloid 4 (TRPV4), mediates Ca2+ influx in the late stage of osteoclast …

Objective. The purpose of this study was to determine the direct effects of lipopolysaccharide
(LPS) on osteoclastogenesis and to assess the ability of calcium hydroxide—Ca (OH) 2—to …

Extracellular vesicles (EVs) are shed by all eukaryotic cells and have emerged as important
intercellular regulators. EVs released by osteoclasts were recently identified as important …

Cell–cell fusion is a fundamental cellular process that is essential for development as well
as fertilization. Myoblast fusion to form multinucleated skeletal muscle myotubes is a well …