Abstract Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase
that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of …

BACKGROUND: With increasing evidence that hydroperoxides are not only toxic but rather
exert essential physiological functions, also hydroperoxide removing enzymes have to be re …

Homocysteine (Hcy) is an amino acid involved in gene methylation. Plasma concentration of
Hcy is elevated in the pathological condition hyperhomocysteinemia (HHcy), which …

Cancer cells produce high amounts of reactive oxygen species (ROS) and evade apoptosis.
Hydroperoxides support proliferation, invasion, migration and angiogenesis, but at higher …

Oxidative stress is defined as an imbalance between generation of reactive oxygen species
(ROS) and decreased antioxidant defense systems. Oxidative stress develops particularly in …

Aurora kinase A (AURKA) is frequently overexpressed in several cancers. miRNA
sequencing and bioinformatics analysis indicated significant downregulation of miR-4715 …

Glutathione peroxidases are well known antioxidant enzymes. They catalyze the reduction
of hydrogen peroxide or organic hydroperoxides using glutathione. Among the reported 8 …

The liver is intimately connected to inflammation, which is the innate defense system of the
body for removing harmful stimuli and participates in the hepatic wound-healing response …

BACKGROUND Changes in DNA methylation may play an important role in the deleterious
reproductive effects reported in association with exposure to environmental pollutants. In this …

Selenium (Se) is an essential micronutrient for humans, acting as a component of the
unusual amino acids, selenocysteine (Se-Cys) and selenomethionine (Se-Met). Where Se …