Heart failure (HF) describes a heterogenous complex spectrum of pathological conditions
that results in structural and functional remodeling leading to subsequent impairment of …

Current therapeutic strategies such as angiogenic therapy and anti-inflammatory therapy for
treating myocardial infarction have limited success. An effective approach may benefit from …

Establishing an appropriate disease model that mimics the complexities of human
cardiovascular disease is critical for evaluating the clinical efficacy and translation success …

Human heart failure, a leading cause of death worldwide, is a prominent example of a
chronic disease that may result from poor cell renewal. The Hippo signaling pathway is an …

Radiation therapy (RT) is an important component of cancer therapy, with> 50% of cancer
patients receiving RT. As the number of cancer survivors increases, the short-and long-term …

Heart failure with preserved ejection fraction (HFpEF) is an emerging disease with signs of
nonresolving inflammation, endothelial dysfunction, and multiorgan defects. Moreover …

Large animal models of cardiac ischemia-reperfusion are critical for evaluation of the
efficacy of cardioprotective interventions prior to clinical translation. Nonetheless, current …

Myocardial Infarction (MI) occurs due to a blockage in the coronary artery resulting in
ischemia and necrosis of cardiomyocytes in the left ventricular heart muscle. The dying …

Lack of significant advancements in early detection and treatment of heart failure have
precipitated the need for discovery of novel biomarkers and therapeutic targets. Over the …

Clinically translatable large animal models have become indispensable for cardiovascular
research, clinically relevant proof of concept studies and for novel therapeutic interventions …