Gene expression is regulated by transcription factors that work together to read cis-
regulatory DNA sequences. The 'cis-regulatory code'—how cells interpret DNA sequences …

Although translational selection to favour codons that match the most abundant tRNAs is not
readily observed in humans, there is nonetheless selection in humans on synonymous …

Sox2 expression in mouse embryonic stem cells (mESCs) depends on a distal cluster of
DNase I hypersensitive sites (DHSs), but their individual contributions and degree of …

Use of synthetic genomics to design and build 'big'DNA has revolutionized our ability to
answer fundamental biological questions by employing a bottom-up approach …

Enhancers are central for the regulation of metazoan transcription but have proven difficult to
study, primarily due to a myriad of interdependent variables shaping their activity …

Genomic context critically modulates regulatory function but is difficult to manipulate
systematically. The murine insulin-like growth factor 2 (Igf2)/H19 locus is a paradigmatic …

Genomes encode for genes and the regulatory signals that enable those genes to be
transcribed, and are continually shaped by evolution. Genomes, including those of human …

Genomic sequences co-evolve with DNA-associated proteins to ensure the multiscale
folding of long DNA molecules into functional chromosomes. In eukaryotes, different …