N6-methyladenosine reader YTHDF family in biological processes: structures, roles, and mechanisms

L Chen, Y Gao, S Xu, J Yuan, M Wang, T Li… - Frontiers in …, 2023 - frontiersin.org
As the most abundant and conserved internal modification in eukaryote RNAs, N6-
methyladenosine (m6A) is involved in a wide range of physiological and pathological …

M6A methylation modification in autoimmune diseases, a promising treatment strategy based on epigenetics

Y Huang, Q Xue, J Chang, Y Wang, C Cheng… - Arthritis Research & …, 2023 - Springer
Abstract Background N6-methyladenosine (m6A) methylation modification is involved in the
regulation of various biological processes, including inflammation, antitumor, and antiviral …

High glucose induces tau hyperphosphorylation in hippocampal neurons via inhibition of ALKBH5-mediated Dgkh m6A demethylation: a potential mechanism for …

M Qu, L Zuo, M Zhang, P Cheng, Z Guo, J Yang… - Cell Death & …, 2023 - nature.com
Tau hyperphosphorylation in hippocampal neurons has an important pathogenetic role in
the development of diabetic cognitive dysfunction. N6-methyladenosine (m6A) methylation …

Exploring the impact of m6A modification on immune diseases: mechanisms and therapeutic implication

Y Chen, M Liu, M Lu, L Luo, Z Han, X Liu - Frontiers in Immunology, 2024 - frontiersin.org
N6-methyladenosine (m6A) is a chemical modification of RNA and has become a widely
discussed topic among scientific researchers in recent years. It is distributed in various …

The m6A Reader YTHDF1 Improves Sevoflurane-Induced Neuronal Pyroptosis and Cognitive Dysfunction Through Augmenting CREB-BDNF Signaling

Y Huang, Y Yang, C Ye, Z Liu, F Wei - Neurochemical Research, 2023 - Springer
Sevoflurane is one of the most widely used anesthetics in surgery which is the main cause of
postoperative cognitive dysfunction (POCD). Previous reports confirmed that YTHDF1 is …

The m6A reader YTHDC2 promotes SIRT3 expression by reducing the stabilization of KDM5B to improve mitochondrial metabolic reprogramming in diabetic …

Y Jiao, S Wang, X Wang, L Yin, YH Zhang, YZ Li… - Acta Diabetologica, 2023 - Springer
Aims Diabetic peripheral neuropathy (DPN) is a common diabetic complication. Aberrant
mitochondrial function causes neurodegeneration under hyperglycemia-induced metabolic …

WTAP participates in neuronal damage by protein translation of NLRP3 in an m6A-YTHDF1-dependent manner after traumatic brain injury

Y Chen, T Long, J Chen, H Wei, J Meng… - … Journal of Surgery, 2024 - journals.lww.com
Background Traumatic brain injury (TBI) is a common complication of acute and severe
neurosurgery. Remodeling of N6-methyladenosine (m6A) stabilization may be an attractive …

METTL14/YTHDC1-mediated m6A modification in hippocampus improves pentylenetetrazol-induced acute seizures

X Zhong, L Chen, Y Wang, Y Liang, Y Huang… - Molecular …, 2024 - Springer
Epilepsy is a common neurological disorder which can cause significant morbidity and
mortality. N6-methyladenosine (m6A), the most common chemical epigenetic modification …

Sevoflurane augments neuroinflammation by regulating DUSP6 via YTHDF1 in postoperative cognitive dysfunction

J Ding, K Zhang, DW Wang, QD Wang - Toxicology Research, 2024 - academic.oup.com
Background Postoperative cognitive dysfunction (POCD) is a generally recognized
complication experienced by patients who receive anesthesia during surgery. Sevoflurane …

[HTML][HTML] The role of m6A RNA methylation in autoimmune diseases: Novel therapeutic opportunities

Y Shan, W Chen, Y Li - Genes & Diseases, 2024 - Elsevier
Abstract N6-methyladenosine (m 6 A) modifications, as one of the most common forms of
internal RNA chemical modifications in eukaryotic cells, have gained increasing attention in …