Targeting microglial autophagic degradation in NLRP3 inflammasome-mediated neurodegenerative diseases
AG Wu, XG Zhou, G Qiao, LU Yu, Y Tang, LU Yan… - Ageing research …, 2021 - Elsevier
Neuroinflammation is considered as a detrimental factor in neurodegenerative diseases,
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …
including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD) …
Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model
Alzheimer disease (AD) is the most common neurodegenerative disease. An imbalance
between the production and clearance of Aβ (amyloid beta) is considered to be actively …
between the production and clearance of Aβ (amyloid beta) is considered to be actively …
[HTML][HTML] Targeting autophagy in Alzheimer's disease: Animal models and mechanisms
XW Zhang, XX Zhu, DS Tang, JH Lu - Zoological research, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disorder that
leads to cognitive impairment and memory loss. Emerging evidence suggests that …
leads to cognitive impairment and memory loss. Emerging evidence suggests that …
[HTML][HTML] Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway
ZG Mei, YG Huang, ZT Feng, YN Luo, SB Yang… - Aging (Albany …, 2020 - ncbi.nlm.nih.gov
Cerebral ischemia/reperfusion (CIR) injury occurs when blood flow is restored in the brain,
causing secondary damage to the ischemic tissues. Previous studies have shown that …
causing secondary damage to the ischemic tissues. Previous studies have shown that …
Sodium butyrate inhibits migration and induces AMPK‐mTOR pathway‐dependent autophagy and ROS‐mediated apoptosis via the miR‐139‐5p/Bmi‐1 axis in …
F Wang, H Wu, M Fan, R Yu, Y Zhang, J Liu… - The FASEB …, 2020 - Wiley Online Library
Bladder cancer is one of the most frequently occurring malignant tumors in the urinary
system. Sodium butyrate (NaB) is a histone deacetylase inhibitor and exerts remarkable …
system. Sodium butyrate (NaB) is a histone deacetylase inhibitor and exerts remarkable …
[HTML][HTML] Photodynamic therapy induces autophagy-mediated cell death in human colorectal cancer cells via activation of the ROS/JNK signaling pathway
C Song, W Xu, H Wu, X Wang, Q Gong, C Liu… - Cell death & …, 2020 - nature.com
Evidence has shown that m-THPC and verteporfin (VP) are promising sensitizers in
photodynamic therapy (PDT). In addition, autophagy can act as a tumor suppressor or a …
photodynamic therapy (PDT). In addition, autophagy can act as a tumor suppressor or a …
[HTML][HTML] A novel missense variant in ACAA1 contributes to early-onset Alzheimer's disease, impairs lysosomal function, and facilitates amyloid-β pathology and …
Alzheimer's disease (AD) is characterized by progressive synaptic dysfunction, neuronal
death, and brain atrophy, with amyloid-β (Aβ) plaque deposits and hyperphosphorylated tau …
death, and brain atrophy, with amyloid-β (Aβ) plaque deposits and hyperphosphorylated tau …
[HTML][HTML] Metformin modulates microbiota-derived inosine and ameliorates methamphetamine-induced anxiety and depression-like withdrawal symptoms in mice
J Yang, Z Zhang, Z Xie, L Bai, P Xiong, F Chen… - Biomedicine & …, 2022 - Elsevier
Background Metformin exhibits therapeutic potential in behavioural deficits induced by
methamphetamine (METH) in rats. Emerging studies suggest gut microbiota may impact …
methamphetamine (METH) in rats. Emerging studies suggest gut microbiota may impact …
Luteolin alleviates methamphetamine-induced neurotoxicity by suppressing PI3K/Akt pathway-modulated apoptosis and autophagy in rats
XH Tan, KK Zhang, JT Xu, D Qu, LJ Chen, JH Li… - Food and Chemical …, 2020 - Elsevier
Methamphetamine (METH) is a highly addictive stimulant that results in serious and
persistent neurotoxic effects. Studies have indicated that luteolin, a flavonoid, may confer …
persistent neurotoxic effects. Studies have indicated that luteolin, a flavonoid, may confer …
Endothelial depletion of Atg7 triggers astrocyte–microvascular disassociation at blood–brain barrier
H Liu, JY Wei, Y Li, M Ban, Q Sun, HJ Wang… - Journal of Cell …, 2023 - rupress.org
Microvascular basement membrane (BM) plays a pivotal role in the interactions of astrocyte
with endothelium to maintain the blood–brain barrier (BBB) homeostasis; however, the …
with endothelium to maintain the blood–brain barrier (BBB) homeostasis; however, the …