The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Anthracyclines currently play a key role in the treatment of many cancers, but the limiting
factor of their use is the widespread phenomenon of drug resistance and untargeted toxicity …

Molecular interactions are key drivers of biological function. Providing interaction resources
to the research community is important since they allow functional interpretation and network …

Highlights•High throughput technologies (HTPs) provide quantitative and multi-dimensional
omics data.•Available HTPs can capture biological alterations in DNA, RNA, protein, and …

The recent years have witnessed the explosive application of sequencing technologies to
study tumor–microenvironment interactions and their role in shaping intratumoral …

Advances in cancer therapeutics have improved patient survival rates. However, cancer
survivors may suffer from adverse events either at the time of therapy or later in life …

Heart disease is the leading cause of death in both men and women. Cardiac fibrosis is the
uncontrolled accumulation of extracellular matrix proteins, which can exacerbate the …

Introduction As a mid-size international pharmaceutical company, we initiated 4 years ago
the launch of a dedicated high-throughput computing platform supporting drug discovery …

In a pharmaceutical context, metabolomics is an underexplored area of research.
Nevertheless, its utility in clinical pathology, biomarker discovery, metabolic subtyping, and …

In line with the advances in high-throughput technologies, multiple omic datasets have
accumulated to study biological systems and diseases coherently. No single omics data type …