For those people with cystic fibrosis carrying rare CFTR mutations not responding to
currently available therapies, there is an unmet need for relevant tissue models for therapy …

Pseudomonas aeruginosa is one of the leading invasive agents of human pulmonary
infection, especially in patients with compromised immunity. Prior studies have used various …

Endothelial hemoglobin (Hb) α regulates endothelial nitric oxide synthase (eNOS)
biochemistry. We hypothesized that Hb could also be expressed and biochemically active in …

Cross-talk between lung epithelial cells and their microenvironment has an important
physiological role in development. Using an in vitro model of differentiation of human …

Background The progenitors to lung airway epithelium that are capable of long-term
propagation may represent an attractive source of cells for cell-based therapies, disease …

Mechanisms regulating gene expression in the airway epithelium underlie its response to
the environment. A network of transcription factors (TFs) and architectural proteins, modulate …

Cell therapies using human induced pluripotent stem cell (hiPSC)-derived nephron
progenitor cells (NPCs) are expected to ameliorate acute kidney injury (AKI). However …

Metabolism is vital to cellular function and tissue homeostasis during human lung
development. In utero, embryonic pluripotent stem cells undergo endodermal differentiation …

Idiopathic pulmonary fibrosis (IPF) is among the illnesses with a high mortality rate, yet no
specific cause has been identified; as a result, successful treatment has not been achieved …

The airway epithelium lining the airways is in first contact with the inhaled environment,
which contains allergens, gaseous pollutants, particulates, and pathogenic microorganisms …