A new platform for high-throughput therapy testing on iPSC-derived lung progenitor cells from cystic fibrosis patients
For those people with cystic fibrosis carrying rare CFTR mutations not responding to
currently available therapies, there is an unmet need for relevant tissue models for therapy …
currently available therapies, there is an unmet need for relevant tissue models for therapy …
Evaluating bacterial pathogenesis using a model of human airway organoids infected with Pseudomonas aeruginosa biofilms
M Tang, S Liao, J Qu, Y Liu, S Han, Z Cai… - Microbiology …, 2022 - Am Soc Microbiol
Pseudomonas aeruginosa is one of the leading invasive agents of human pulmonary
infection, especially in patients with compromised immunity. Prior studies have used various …
infection, especially in patients with compromised immunity. Prior studies have used various …
Somatic cell hemoglobin modulates nitrogen oxide metabolism in the human airway epithelium
N Marozkina, L Smith, Y Zhao, J Zein, JF Chmiel… - Scientific Reports, 2021 - nature.com
Endothelial hemoglobin (Hb) α regulates endothelial nitric oxide synthase (eNOS)
biochemistry. We hypothesized that Hb could also be expressed and biochemically active in …
biochemistry. We hypothesized that Hb could also be expressed and biochemically active in …
[HTML][HTML] Enhancement of airway epithelial cell differentiation by pulmonary endothelial cell co-culture
U Burkhanova, A Harris, SH Leir - Stem cell research, 2022 - Elsevier
Cross-talk between lung epithelial cells and their microenvironment has an important
physiological role in development. Using an in vitro model of differentiation of human …
physiological role in development. Using an in vitro model of differentiation of human …
Expandable lung epithelium differentiated from human embryonic stem cells
H Kotasová, M Capandová, V Pelková… - Tissue Engineering and …, 2022 - Springer
Background The progenitors to lung airway epithelium that are capable of long-term
propagation may represent an attractive source of cells for cell-based therapies, disease …
propagation may represent an attractive source of cells for cell-based therapies, disease …
The Bromodomain Containing 8 (BRD8) transcriptional network in human lung epithelial cells
Mechanisms regulating gene expression in the airway epithelium underlie its response to
the environment. A network of transcription factors (TFs) and architectural proteins, modulate …
the environment. A network of transcription factors (TFs) and architectural proteins, modulate …
In vitro methods to ensure absence of residual undifferentiated human induced pluripotent stem cells intermingled in induced nephron progenitor cells
H Tsujimoto, N Katagiri, Y Ijiri, B Sasaki, Y Kobayashi… - PLoS …, 2022 - journals.plos.org
Cell therapies using human induced pluripotent stem cell (hiPSC)-derived nephron
progenitor cells (NPCs) are expected to ameliorate acute kidney injury (AKI). However …
progenitor cells (NPCs) are expected to ameliorate acute kidney injury (AKI). However …
[HTML][HTML] Metabolomic profiling of human pluripotent stem cell differentiation into lung progenitors
Metabolism is vital to cellular function and tissue homeostasis during human lung
development. In utero, embryonic pluripotent stem cells undergo endodermal differentiation …
development. In utero, embryonic pluripotent stem cells undergo endodermal differentiation …
Induced Pluripotent stem-cells inhibit experimental bleomycin-induced pulmonary fibrosis through regulation of the insulin-like growth factor signaling
P Bayati, M Taherian… - Iranian Journal of …, 2022 - publish.kne-publishing.com
Idiopathic pulmonary fibrosis (IPF) is among the illnesses with a high mortality rate, yet no
specific cause has been identified; as a result, successful treatment has not been achieved …
specific cause has been identified; as a result, successful treatment has not been achieved …
The air–liquid interface model
TL Hackett, GF Vasse, AM van der Does, B Rae… - 3D Lung Models for …, 2022 - Elsevier
The airway epithelium lining the airways is in first contact with the inhaled environment,
which contains allergens, gaseous pollutants, particulates, and pathogenic microorganisms …
which contains allergens, gaseous pollutants, particulates, and pathogenic microorganisms …