Recent advances on biologically active coumarin-based hybrid compounds
Coumarin hybrids have been designed and synthesized as an important new strategy in the
field of medicinal chemistry. Coumarin core has been shown to form various compounds to …
field of medicinal chemistry. Coumarin core has been shown to form various compounds to …
Physicochemical properties, drug likeness, ADMET, DFT studies, and in vitro antioxidant activity of oxindole derivatives
Poor pharmacokinetic and safety profiles create significant hurdles in the drug development
process. This work focuses on a detailed understanding of drug discovery interplay among …
process. This work focuses on a detailed understanding of drug discovery interplay among …
Isatin Derivatives: A Frontier in Antimicrobial Agents
S Shaik, M Chaudhary, C Kaur… - Letters in Organic …, 2024 - ingentaconnect.com
Microbial infection is one of the major concerns for human health in the modern era.
Condition is further worsening due to the development of resistance by the microbe against …
Condition is further worsening due to the development of resistance by the microbe against …
Design, synthesis, biological evaluation, kinetic studies and molecular modeling of imidazo-isoxazole derivatives targeting both α-amylase and α-glucosidase …
E AlRashidi, S Ghannay, AEAE Albadri, M Abid… - Heliyon, 2024 - cell.com
Herein, a novel set of imidazo-isoxazole derivatives containing thiourea and urea scaffolds
were synthesized, characterized (1 H NMR, 13 C NMR, and elemental analysis). These …
were synthesized, characterized (1 H NMR, 13 C NMR, and elemental analysis). These …
Physicochemical properties, pharmacokinetic studies, DFT approach, and antioxidant activity of nitro and chloro indolinone derivatives
The process of developing of new drugs is greatly hampered by their inadequate
physicochemical, pharmacokinetic, and intrinsic characteristics. In this regard, the selected …
physicochemical, pharmacokinetic, and intrinsic characteristics. In this regard, the selected …
Dual inhibition of S. aureus TyrRS and S. aureus gyrase by two 4-amino-4′-acetyldiphenyl sulfide-based Schiff bases: structural features, DFT study, Hirshfeld …
Abstract Two 4-amino-4′-acetyldiphenyl sulfide-based Schiff bases, namely 1-[4-({4-[(E)-(2-
hydroxynaphthalen-1-yl) methylideneamino] phenyl} sulfanyl)-phenyl] ethanone (I) and (E)-1 …
hydroxynaphthalen-1-yl) methylideneamino] phenyl} sulfanyl)-phenyl] ethanone (I) and (E)-1 …
Design, synthesis, antimicrobial evaluation, molecular docking studies, and in silico prediction of ADME properties for novel pyrazolo [1, 5‐a] pyrimidine and its fused …
FBN Eldeen, SAS Mousa, IMM Othman… - Journal of …, 2024 - Wiley Online Library
Dienamine 2 was synthesized by reacting 5‐aminopyrazole 1 with two moles of (DMF DMA).
Enamine 2 underwent subsequent reactions with various reagents in different reaction …
Enamine 2 underwent subsequent reactions with various reagents in different reaction …
Synthesis, characterization and DFT studies of novel Schiff base derivatives of curcumin as potential antibacterial agents
M Patel, T Kikani, K Patel, S Thakore - Journal of Molecular Structure, 2024 - Elsevier
Curcumin has immense medicinal value in traditional medicine and is known to have anti-
tumor, anti-microbial and anti-oxidant properties. Molecular structure of curcumin has a very …
tumor, anti-microbial and anti-oxidant properties. Molecular structure of curcumin has a very …
The first example of a cine-substitution in a series of 1, 3-dinitropyrazoles
TK Shkineva, SA Krasnova, IL Dalinger - Chemistry of Heterocyclic …, 2024 - Springer
The first example of a cine-substitution in a series of 1,3-dinitropyrazoles | Chemistry of
Heterocyclic Compounds Skip to main content SpringerLink Account Menu Find a journal …
Heterocyclic Compounds Skip to main content SpringerLink Account Menu Find a journal …
Первый пример кине-замещения в ряду 1, 3-динитропиразолов
TK Shkineva, SА Krasnova, IL Dalinger - Chemistry of Heterocyclic …, 2024 - osi131.osi.lv
В литературе описан единственный пример кинезамещения N-нитропиразола,
содержащего нитрогруппу в положении 3,–взаимодействие 1, 3, 4-тринитропиразола с …
содержащего нитрогруппу в положении 3,–взаимодействие 1, 3, 4-тринитропиразола с …