Individualizing patient treatment is a core objective of the medical field. Reaching this
objective has been elusive owing to the complex set of factors contributing to both disease …

Squamous cell carcinoma of the head and neck (SCCHN) is among the most prevalent
cancer types worldwide. Despite multimodal therapeutic approaches that include surgical …

Importance To date, the benefit of genome-driven cancer therapy has not been quantified.
Objective We sought to estimate the annual percentage of patients in the United States with …

Profiling tumors at single-cell resolution provides an opportunity to understand complexities
underpinning lymph-node metastases in head and neck squamous-cell carcinoma. Single …

Chemo-resistance is one of the major causes of cancer-related deaths. Here we used single-
cell transcriptomics to investigate divergent modes of chemo-resistance in tumor cells. We …

Current algorithms for the clinical management of patients with squamous cell carcinoma of
the head and neck (HNSCC) are based on a stage-dependent strategy where all patients at …

Targeting EGFR is a validated approach in the treatment of squamous-cell cancers (SCCs),
although there are no established biomarkers for predicting response. We have identified a …

Motivation As we move toward an era of precision medicine, the ability to predict patient-
specific drug responses in cancer based on molecular information such as gene expression …

Although combination therapy is the standard of care for relapsed/refractory non-Hodgkin's
lymphoma (RR-NHL), combination treatment chosen for an individual patient is empirical …

Cancer frequency and prevalence have been increasing in the past decades, with
devastating impacts on patients and their families. Despite the great advances in targeted …