The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …

Abstract Potassium channels (K+-channels) selectively control the passive flow of potassium
ions across biological membranes and thereby also regulate membrane excitability. Genetic …

Numerous neurodegenerative diseases result from altered ion channel function and
mutations. The intracellular redox status can significantly alter the gating characteristics of …

Mild cognitive impairment (MCI) is a common trait of Parkinson's disease (PD), often
associated with early motor deficits, eventually evolving to PD with dementia in later disease …

Abstract Parkinson's disease (PD), a neurodegenerative disorder, is one of the most
significant challenges confronting modern societies, affecting millions of patients globally …

Lysosomes are membrane-bound organelles with an acidic lumen and are traditionally
characterized as a recycling center in cells. Lysosomal ion channels are integral membrane …

Parkinson's disease (PD) is the second largest group of neurodegenerative diseases, and
its existing drug treatments are not satisfactory. Natural cell membrane drugs are used for …

Adenosine triphosphate (ATP) is an important purine molecule. It widely exists in cells and is
closely related to a variety of significant physiological and pathological processes, such as …

Healthy brains display a wide range of firing patterns, from synchronized oscillations during
slow-wave sleep to desynchronized firing during movement. These physiological activities …

The inwardly rectifying potassium Kir4. 2 channel plays a crucial role in regulating
membrane potentials and maintaining potassium homeostasis. Kir4. 2 has been implicated …