Age-related change in human haematopoiesis causes reduced regenerative capacity,
cytopenias, immune dysfunction and increased risk of blood cancer,–, but the reason for …

Clonal hematopoiesis (CH) arises when a substantial proportion of mature blood cells is
derived from a single hematopoietic stem cell lineage. Using whole-genome sequencing of …

Gout is a common inflammatory arthritis caused by precipitation of monosodium urate (MSU)
crystals in individuals with hyperuricemia. Acute flares are accompanied by secretion of …

Clonal hematopoiesis of indeterminate potential (CHIP) is a common form of age-related
somatic mosaicism that is associated with significant morbidity and mortality. CHIP mutations …

There is a growing body of evidence that therapy-related myeloid neoplasms (t-MNs) with
driver gene mutations arise in the background of clonal hematopoiesis (CH) under the …

Mutations in a diverse set of driver genes increase the fitness of haematopoietic stem cells
(HSCs), leading to clonal haematopoiesis. These lesions are precursors for blood cancers …

Hematopoietic stem cell aging, through the acquisition of somatic mutations, gives rise to
clonal hematopoiesis (CH). While a high prevalence of CH has been described in otherwise …

Somatic mutations accumulate in all cells with age and can confer a selective advantage,
leading to clonal expansion over time. In hematopoietic cells, mutations in a subset of genes …

Background Clonal hematopoiesis of indeterminate potential (CHIP), the age-related
expansion of mutant hematopoietic stem cells, confers risk for multiple diseases of aging …

Human aging is marked by the emergence of a tapestry of clonal expansions in dividing
tissues, particularly evident in blood as clonal hematopoiesis (CH). CH, linked to cancer risk …