The structure of the nuclear pore complex (an update)
The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …
The nuclear pore complex as a flexible and dynamic gate
KE Knockenhauer, TU Schwartz - Cell, 2016 - cell.com
Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary
transport gates for molecular exchange between nucleus and cytoplasm. Stripping the …
transport gates for molecular exchange between nucleus and cytoplasm. Stripping the …
TMEM proteins in cancer: a review
K Schmit, C Michiels - Frontiers in pharmacology, 2018 - frontiersin.org
A transmembrane protein (TMEM) is a type of protein that spans biological membranes.
Many of them extend through the lipid bilayer of the plasma membrane but others are …
Many of them extend through the lipid bilayer of the plasma membrane but others are …
Structure and function of the nuclear pore complex
The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …
Implications of a multiscale structure of the yeast nuclear pore complex
CW Akey, I Echeverria, C Ouch, I Nudelman, Y Shi… - Molecular Cell, 2023 - cell.com
Nuclear pore complexes (NPCs) direct the nucleocytoplasmic transport of macromolecules.
Here, we provide a composite multiscale structure of the yeast NPC, based on improved 3D …
Here, we provide a composite multiscale structure of the yeast NPC, based on improved 3D …
Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions
M Raices, MA D'angelo - Nature reviews Molecular cell biology, 2012 - nature.com
Nuclear pore complexes (NPCs) are multiprotein aqueous channels that penetrate the
nuclear envelope connecting the nucleus and the cytoplasm. NPCs consist of multiple …
nuclear envelope connecting the nucleus and the cytoplasm. NPCs consist of multiple …
The nuclear pore complex: birth, life, and death of a cellular behemoth
Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …
Orchestrating nuclear envelope disassembly and reassembly during mitosis
S Güttinger, E Laurell, U Kutay - Nature reviews Molecular cell biology, 2009 - nature.com
Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …
Protein homeostasis: live long, won't prosper
BH Toyama, MW Hetzer - Nature reviews Molecular cell biology, 2013 - nature.com
Protein turnover is an effective way of maintaining a functional proteome, as old and
potentially damaged polypeptides are destroyed and replaced by newly synthesized copies …
potentially damaged polypeptides are destroyed and replaced by newly synthesized copies …
Optically Pure Double-Stranded Dinuclear Ir (III) Metallohelices Enabled Chirality-Induced Photodynamic Responses
X Li, Z Wang, X Hao, J Zhang, X Zhao… - Journal of the …, 2023 - ACS Publications
Investigation on the interactions between enantiomers of chiral drugs and biomolecules can
help precisely understand their biological behaviors in vivo and provide insights into the …
help precisely understand their biological behaviors in vivo and provide insights into the …