The nuclear pore complex (NPC) serves as the sole bidirectional gateway of
macromolecules in and out of the nucleus. Owing to its size and complexity (∼ 1,000 protein …

Nuclear pore complexes (NPCs) perforate the nuclear envelope and serve as the primary
transport gates for molecular exchange between nucleus and cytoplasm. Stripping the …

A transmembrane protein (TMEM) is a type of protein that spans biological membranes.
Many of them extend through the lipid bilayer of the plasma membrane but others are …

The nucleus, a genome-containing organelle eponymous of eukaryotes, is enclosed by a
double membrane continuous with the endoplasmic reticulum. The nuclear pore complex …

Nuclear pore complexes (NPCs) direct the nucleocytoplasmic transport of macromolecules.
Here, we provide a composite multiscale structure of the yeast NPC, based on improved 3D …

Nuclear pore complexes (NPCs) are multiprotein aqueous channels that penetrate the
nuclear envelope connecting the nucleus and the cytoplasm. NPCs consist of multiple …

Nuclear pore complexes (NPCs) are the only transport channels that cross the nuclear
envelope. Constructed from~ 500–1000 nucleoporin proteins each, they are among the …

Cell division in eukaryotes requires extensive architectural changes of the nuclear envelope
(NE) to ensure that segregated DNA is finally enclosed in a single cell nucleus in each …

Protein turnover is an effective way of maintaining a functional proteome, as old and
potentially damaged polypeptides are destroyed and replaced by newly synthesized copies …

Investigation on the interactions between enantiomers of chiral drugs and biomolecules can
help precisely understand their biological behaviors in vivo and provide insights into the …