Background Acute respiratory distress syndrome (ARDS) is a common, but under-
recognised, critical illness syndrome associated with high mortality. An important factor in its …

Background Failure to reliably diagnose ARDS may be a major driver of negative clinical
trials and underrecognition and treatment in clinical practice. We sought to examine the …

Background Existing prediction models for acute respiratory distress syndrome (ARDS)
require manual chart abstraction and have only fair performance–limiting their suitability for …

Background Management of mechanical ventilation (MV) is an important and complex
aspect of caring for critically ill patients. Management strategies and technical operation of …

The COVID‐19 pandemic has produced critical shortages of ventilators worldwide. There is
an unmet need for rapidly deployable, emergency‐use ventilators with sufficient functionality …

There are many barriers to the implementation of evidence-based practice in critical care
medicine. Systematically classifying these barriers allows implementation researchers and …

Rationale: Prone positioning reduces mortality in patients with severe acute respiratory
distress syndrome (ARDS), a feature of severe coronavirus disease 2019 (COVID-19) …

OBJECTIVES: Hyper-and hypoinflammatory subphenotypes discovered in patients with
acute respiratory distress syndrome predict clinical outcomes and therapeutic responses …

Background: Severe alcohol withdrawal syndrome (SAWS) is highly morbid, costly, and
common among hospitalized patients, yet minimal evidence exists to guide inpatient …

Objectives: Mechanical ventilation with low tidal volumes is recommended for all patients
with acute respiratory distress syndrome and may be beneficial to other intubated patients …