Mechanisms of congenital malformations in pregnancies with pre-existing diabetes

MR Loeken - Current diabetes reports, 2020 - Springer
Abstract Purpose of Review Fetuses of diabetic mothers are at increased risk for congenital
malformations. Research in recent decades using animal and embryonic stem cell models …

Multifaceted protective role of glucosamine against osteoarthritis: review of its molecular mechanisms

HM Al-Saadi, KL Pang, S Ima-Nirwana… - Scientia Pharmaceutica, 2019 - mdpi.com
Osteoarthritis (OA) is a joint disease resulting from cartilage degeneration and causing joint
pain and stiffness. Glucosamine exerts chondroprotective effects and effectively reduces OA …

Diabetic Embryopathy Susceptibility in Mice Is Associated with Differential Dependence on Glucosamine and Modulation of High Glucose-Induced Oxidative Stress

JH Jung, MR Loeken - Antioxidants, 2021 - mdpi.com
The high KM glucose transporter, GLUT2 (SLC2A2), is expressed by embryos and causes
high rates of glucose transport during maternal hyperglycemic episodes in diabetic …

Glucose metabolism regulates expression of hair-inductive genes of dermal papilla spheres via histone acetylation

M Choi, YM Choi, SY Choi, IS An, S Bae, S An… - Scientific Reports, 2020 - nature.com
Cellular metabolism is one of the crucial factors to regulate epigenetic landscape in various
cells including immune cells, embryonic stem cells and hair follicle stem cells. Dermal …

Sema4D Deficiency Enhances Glucose Tolerance Through Acceleration of GLUT2 Synthesis in Hepatocytes

Y Zhang, X Jiang, D Wu, H Huang, G Jia, G Zhao - 2024 - researchsquare.com
Abstract The glucose transporter 2 (GLUT2) is constitutively expressed in pancreatic beta
cells and hepatocytes in mice. It is the most important receptor in glucose-stimulated insulin …

Direct conversion from skin fibroblasts to functional dopaminergic neurons for biomedical application

Y Jang, JH Jung - Biomedical Dermatology, 2017 - Springer
Recent progress in tissue engineering research led to the generation of different types of
cells from a handful of skin tissue. Lineage reprogramming is a nascent field, which holds …