The current emphasis on comparative effectiveness research will provide practicing
physicians with increasing volumes of observational evidence about preventive care …

Epidemiologic studies have, variably, shown the concomitant use of statin drugs to be
beneficial to cancer outcomes. Statin drugs have been FDA approved for three decades for …

Background Accumulating evidence suggests that statins affect diseases other than
cardiovascular disease, including cancer, and that these effects may depend on the lipid …

Background Cancer is emerging as a major problem globally, as it accounts for the second
cause of death despite medical advances. According to epidemiological and basic studies …

Importance of the field: HMG-CoA inhibitors (statins), a class of drugs that reduce
cholesterol, are used to manage and prevent coronary heart disease. They are among the …

Patients who adhere to preventive therapies may be more likely to engage in a broad
spectrum of behaviors consistent with a healthy lifestyle. Because many of these behaviors …

Background: Statins are effective in preventing cardiovascular events, but patients do not
fully adhere to them. Objective: To determine whether patients are more adherent to generic …

Statins inhibit 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase, the rate-
limiting enzyme in cholesterol biosynthesis, which converts HMG-CoA to mevalonate …

Statins are widely used in the evidence-based lowering of cardiovascular disease (CVD)
risk. The use of these drugs for secondary prevention of CVD is well founded, but their …

Purpose Estimating drug effectiveness and safety among older adults in population‐based
studies using administrative health care claims can be hampered by unmeasured …