Isoxazole ring as a useful scaffold in a search for new therapeutic agents
A Sysak, B Obmińska-Mrukowicz - European journal of medicinal chemistry, 2017 - Elsevier
Due to its relatively easy synthesis, isoxazole ring has been as an object of interest for
chemists and pharmacologists from research groups all over the world. Its chemical …
chemists and pharmacologists from research groups all over the world. Its chemical …
The synthetic and therapeutic expedition of isoxazole and its analogs
Isoxazole, constituting an important family of five-membered heterocycles with one oxygen
atom and one nitrogen atom at adjacent positions is of immense importance because of its …
atom and one nitrogen atom at adjacent positions is of immense importance because of its …
Voltage gated sodium channel inhibitors as anticonvulsant drugs: A systematic review on recent developments and structure activity relationship studies
Voltage-gated sodium channel blockers are one of the vital targets for the management of
several central nervous system diseases, including epilepsy, chronic pain, psychiatric …
several central nervous system diseases, including epilepsy, chronic pain, psychiatric …
Benzisoxazole: a privileged scaffold for medicinal chemistry
KP Rakesh, CS Shantharam, MB Sridhara… - …, 2017 - pubs.rsc.org
The benzisoxazole analogs represent one of the privileged structures in medicinal chemistry
and there has been an increasing number of studies on benzisoxazole-containing …
and there has been an increasing number of studies on benzisoxazole-containing …
Reactive metabolites of the anticonvulsant drugs and approaches to minimize the adverse drug reaction
Several generations of antiepileptic drugs (AEDs) are available in the market for the
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
treatment of seizures, but these are amalgamated with acute to chronic side effects. The …
Recent progress in the synthesis of isoxazoles
DX Duc, VC Dung - Current Organic Chemistry, 2021 - ingentaconnect.com
Isoxazole derivatives are aromatic five-membered ring heterocyclic compounds with one
oxygen atom and one nitrogen atom at adjacent positions. These compounds have a broad …
oxygen atom and one nitrogen atom at adjacent positions. These compounds have a broad …
The Isoxazole Ring and Its N‐Oxide: A Privileged Core Structure in Neuropsychiatric Therapeutics
Mental disorders are neuropsychiatric conditions that are marked by unusual or irregular
thinking, feelings, or behavior, and lead to distress and/or impaired functions. Major …
thinking, feelings, or behavior, and lead to distress and/or impaired functions. Major …
Domino hydrogenation–reductive amination of phenols, a simple process to access substituted cyclohexylamines
VR Jumde, E Petricci, C Petrucci, N Santillo… - Organic …, 2015 - ACS Publications
Phenols can be efficiently reduced by sodium formate and Pd/C as the catalyst in water and
in the presence of amines to give the corresponding cyclohexylamines. This reaction works …
in the presence of amines to give the corresponding cyclohexylamines. This reaction works …
Design and synthesis of chroman derivatives with dual anti-breast cancer and antiepileptic activities
P Rawat, SM Verma - Drug Design, Development and Therapy, 2016 - Taylor & Francis
A series of chroman derivatives was designed, prepared, and examined for their anti-breast
cancer and antiepileptic activities. All synthesized compounds yielded results that were in …
cancer and antiepileptic activities. All synthesized compounds yielded results that were in …
Multifunctional hybrid compounds derived from 2-(2, 5-dioxopyrrolidin-1-yl)-3-methoxypropanamides with anticonvulsant and antinociceptive properties
M Abram, M Zagaja, S Mogilski… - Journal of Medicinal …, 2017 - ACS Publications
The focused set of new pyrrolidine-2, 5-diones as potential broad-spectrum hybrid
anticonvulsants was described. These derivatives integrate on the common structural …
anticonvulsants was described. These derivatives integrate on the common structural …