Advances in biodegradable and injectable hydrogels for biomedical applications

Y Li, HY Yang, DS Lee - Journal of Controlled Release, 2021 - Elsevier
In situ-forming injectable hydrogels are smart biomaterials that can be implanted into living
bodies with minimal invasion. Due to pioneer work of Prof. Sung Wan Kim in this field …

Designing degradable hydrogels for orthogonal control of cell microenvironments

PM Kharkar, KL Kiick, AM Kloxin - Chemical Society Reviews, 2013 - pubs.rsc.org
Degradable and cell-compatible hydrogels can be designed to mimic the physical and
biochemical characteristics of native extracellular matrices and provide tunability of …

Injectable hydrogels for sustained release of therapeutic agents

T Thambi, Y Li, DS Lee - Journal of Controlled Release, 2017 - Elsevier
Hydrogels are natural or synthetic polymer networks that exhibit high water absorbent
capacities and have been used as scaffolds for tissue engineering or as delivery carriers for …

In situ gelling pH-and temperature-sensitive biodegradable block copolymer hydrogels for drug delivery

NK Singh, DS Lee - Journal of Controlled Release, 2014 - Elsevier
Stimuli-sensitive injectable polymeric hydrogels have been extensively investigated during
the past decade as bioactive agent delivery vehicles and for tissue engineering applications …

Temperature-responsive compounds as in situ gelling biomedical materials

HJ Moon, MH Park, MK Joo, B Jeong - Chemical Society Reviews, 2012 - pubs.rsc.org
Aqueous solutions that undergo sol-to-gel transition as the temperature increases have
been extensively studied during the last decade. The material can be designed by …

Injectable polymeric hydrogels for the delivery of therapeutic agents: A review

QV Nguyen, JH Park, DS Lee - European Polymer Journal, 2015 - Elsevier
Since drug delivery systems have become one of the most promising areas of human health
related research, the applications of biomaterials such as hydrogels have been widely …

Biodegradable and injectable hydrogels in biomedical applications

Y Li, HY Yang, DS Lee - Biomacromolecules, 2022 - ACS Publications
Injectable hydrogels are a unique class of hydrogels that are formed upon injection into
living bodies. They possess features of typical hydrogels such as softness, 3D network …

Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine

MK Nguyen, E Alsberg - Progress in polymer science, 2014 - Elsevier
Polymer hydrogels have been widely explored as therapeutic delivery matrices because of
their ability to present sustained, localized and controlled release of bioactive factors …

Injectable block copolymer hydrogels: achievements and future challenges for biomedical applications

CT Huynh, MK Nguyen, DS Lee - Macromolecules, 2011 - ACS Publications
In the past two decades, physical polymeric hydrogels have been extensively explored for
biomedical applications, such as drug delivery and tissue engineering. These hydrogels …

A long-acting formulation of a polypeptide drug exenatide in treatment of diabetes using an injectable block copolymer hydrogel

K Li, L Yu, X Liu, C Chen, Q Chen, J Ding - Biomaterials, 2013 - Elsevier
This study is aimed to develop a long-acting injectable formulation in treatment of type II
diabetes. A glucoregulatory polypeptide, exenatide (EXT), was chosen as the model drug …