Immunotherapy exerts its excellent anti-tumor effects by stimulating and enhancing the
immune response of the body, and has become another important class of anti-tumor …

Highlights•Comprehensive TME characterization is required to understand therapy
resistance and sensitivity to current generations of therapeutics•Spatial profiling has …

Mucosal head and neck squamous cell carcinoma (HNSCC) are the seventh most common
cancer, with approximately 50% of patients living beyond 5 years. Immune checkpoint …

Head and neck squamous cell carcinomas (HNSCCs) are the seventh most common cancer
and represent a global health burden. Immune checkpoint inhibitors (ICIs) have shown …

Purpose This study aims to investigate the prognostic value of composition and spatial
architecture of tumor-infiltrating lymphocytes (TILs) as well as PDL1 expression on TILs …

Despite tremendous progress made in the diagnosis and managements, head and neck
squamous cell carcinoma (HNSC) remains a global medical dilemma with dismal clinical …

Background Recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC)
generally has a poor prognosis for patients with limited treatment options. While …

Head and neck squamous cell carcinoma (HNSCC) is one of the most common tumor
entities worldwide, with human papillomavirus (HPV) infection contributing to cancer …

Head and neck squamous cell carcinoma (HNSCC) is experiencing a rising incidence and
mortality worldwide, emphasizing the need for reliable prognostic markers. Tumor-infiltrating …

Head and neck cancers (HNC) are aggressive, difficult-to-treat tumors that can be caused by
genetic factors but mainly by lifestyle or infection caused by the human papillomavirus. As …