Pacific populations have long been observed to suffer a high burden of metabolic disease,
including obesity, type 2 diabetes and gout. The 'Thrifty Genotype'hypothesis has frequently …

Malnutrition substantially increases susceptibility to Entamoeba histolytica in children. Leptin
is a hormone produced by adipocytes that inhibits food intake, influences the immune …

Objective Hyperphagia and early-onset, severe obesity are clinical characteristics of rare
melanocortin-4 receptor (MC4R) pathway diseases due to loss-of-function (LOF) variants in …

Abstract Various Pacific Island populations have experienced a marked increase in the
prevalence of obesity in past decades. This study examined the association of a promoter …

Obesity and related morbidities pose a major health threat. Obesity is associated with
increased blood concentrations of the anorexigenic hormone leptin; however, obese …

OBJECTIVE: The aim of the study was to investigate whether adiposity and metabolic
markers, such as leptin, glucose, and lipids, are influenced by leptin (LEP) and leptin …

The increasing prevalence of obesity in urban Indian children is indicative of an impending
crisis of metabolic disorders. Although perturbations in the secretion of adipokines and …

Adipocytokines are produced by visceral fat, and levels may be associated with breast
cancer risk. We investigated whether single nucleotide polymorphisms (SNPs) in …

The leptin receptor (LEPR) is a key gene in the control of food intake and energy
homeostasis. The sequence variant LEPR {NM_001024587. 1}: c. 1987C> T has been …

The adipocytokine leptin links nutritional status to immune function. Leptin signaling protects
from amebiasis, but the molecular mechanism is not understood. We developed an in vitro …