Multiple sclerosis (MS) is a neurological disorder affecting the central nervous system and
features extensive functional brain changes that are poorly understood but relate strongly to …

Multiple sclerosis is a neuroinflammatory and neurodegenerative disorder of the central
nervous system that can be considered a network disorder. In MS, lesional pathology …

Being immune privileged, the central nervous system (CNS) is constituted by unique
parenchymal and non-parenchymal tissue-resident macrophages, namely, microglia and …

Background Mild cognitive impairment (MCI) depicts a transitory phase between healthy
elderly and the onset of Alzheimer's disease (AD) with worsening cognitive impairment …

Objectives To evaluate the diffusion kurtosis and susceptibility change in the U-fiber region
of patients with relapsing–remitting multiple sclerosis (pwRRMS) and their correlations with …

Background Axons and myelin sheaths are the physical foundation for white matter (WM) to
perform normal functions. Our previous study found the metabolite abnormalities in frontal …

The PRISM project, funded by the EU's Innovative Medicines Initiative, has identified a
transdiagnostic, pathophysiological relationship between the integrity of the default mode …

It is increasingly recognized that cognitive symptoms are a common sequelae of relapsing-
remitting multiple sclerosis and are associated with adverse functional consequences …

Background Cognitive impairment is one of the common symptoms in patients with
neuromyelitis optica spectrum disorder (NMOSD). However, the underlying mechanism …

Introduction: Cognitive neuroscience explores the mechanisms of cognition by studying its
structural and functional brain correlates. Many studies have combined structural and …