Multiple endocrine neoplasia (MEN) is characterized by the occurrence of tumors involving
two or more endocrine glands within a single patient. Four major forms of MEN, which are …

The progression from cardiac injury to symptomatic heart failure has been intensely studied
over the last decade, and is largely attributable to a loss of functional cardiac myocytes …

This volume covers tumors of the pituary, the thyroid and parathyroid, the adrenal gland, the
endocrine pancreas, and inherited tumor syndromes. Each entity is extensively discussed …

Astrocyte dysfunction and inflammation are associated with the pathogenesis of major
depressive disorder (MDD). However, the mechanisms underlying these effects remain …

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder
characterized by the occurrence of tumors of the parathyroids, pancreas, and anterior …

Abundant data support a key role for the transcription factor nuclear factor-κB (NF-κB)
signaling pathway in controlling the initiation and progression of human cancer. NF-κB and …

The cellular function of the menin tumor suppressor protein, product of the MEN1 gene
mutated in familial multiple endocrine neoplasia type 1, has not been defined. We now show …

Single-stranded DNA (ssDNA) forms continuously during DNA replication and is an
important intermediate during recombination-mediated repair of damaged DNA. Replication …

The protein menin is encoded by the MEN1 gene, which is mutated in patients with multiple
endocrine neoplasia type 1 (MEN1) syndrome. Although menin acts as a tumor suppressor …

RNA interference (RNAi) mediated by short interfering RNAs (siRNAs) is a widely used
method to analyze gene function. To use RNAi knockdown accurately to infer gene function …