Gene transfer for the therapeutic modulation of cardiovascular diseases is an expanding
area of gene therapy. During the last decade several approaches have been designed for …

Angiogenic therapy, which involves the use of an exogenous stimulus to promote blood
vessel growth, is an attractive approach for the treatment of ischemic diseases. It has been …

In a cell-free approach to regenerative therapeutics, transient application of paracrine factors
in vivo could be used to alter the behavior and fate of progenitor cells to achieve sustained …

Aims The objective of this study was to investigate whether vascular endothelial growth
factor (VEGF) secreted by mesenchymal stem cells (MSC) improves myocardial survival and …

Background—Mesenchymal stem cell (MSC)-based regenerative strategies were
investigated to treat acute myocardial infarction and improve left ventricular function …

Human adipose-derived stem cells (ASCs) secrete cytokines and growth factors that can be
harnessed in a paracrine fashion for promotion of angiogenesis, cell survival, and activation …

Distinct families of multipotent heart progenitors play a central role in the generation of
diverse cardiac, smooth muscle and endothelial cell lineages during mammalian …

Current pharmacologic therapy for ischemic heart disease suffers multiple limitations such
as compliance issues and side effects of medications. Revascularization procedures often …

Therapeutic angiogenesis promises to aid the healing and regeneration of tissues suffering
from a compromised vascular supply. Ischaemia therapy has so far primarily focused on …

Background/Aims: Vagus nerve stimulation (VNS) suppresses arrhythmic activity and
minimizes cardiomyocyte injury. However, how VNS affects angiogenesis/arteriogenesis in …