G protein–coupled receptors (GPCRs) are a large family comprising> 800 signaling
receptors that regulate numerous cellular and physiologic responses. GPCRs have been …

Many of the fundamental concepts of signal transduction and kinase activity are attributed to
the discovery and crystallization of cAMP-dependent protein kinase, or protein kinase A …

Carboxy-terminus of Hsc70-interacting protein (CHIP) functions both as a molecular co-
chaperone and ubiquitin E3 ligase playing a critical role in modulating the degradation of …

G-protein coupled receptor (GPCR) mediated calcium (Ca 2+)-signaling transduction
remains crucial in designing drugs for various complex diseases including …

Abstract The 3′, 5′-cyclic adenosine monophosphate (cAMP) dependent protein kinase
(PKA) is a tetrameric holoenzyme comprising a set of two regulatory subunits (PKA-R) and …

Primary cilia are microtubule-based, non-motile sensory organelles present in most types of
growth-arrested eukaryotic cells. They are transduction hubs that receive and transmit …

Mutations in the catalytic subunit of protein kinase A (PKAc) drive the stress hormone
disorder adrenal Cushing's syndrome. We define mechanisms of action for the PKAc-L205R …

Cyclic AMP (cAMP) is a pivotal signaling molecule existing in almost all living organisms.
However, the mechanism of cAMP signaling in plants remains very poorly understood. Here …

Compartmentalization of diverse types of signaling molecules contributes to the precise
coordination of signal propagation. The primary cilium fulfills this function by acting as a …

Ubiquitin is a small eukaryotic protein so named for its cellular abundance and originally
recognized for its role as the posttranslational modification (PTM)“tag” condemning …