[HTML][HTML] Alcoholic liver disease: pathogenesis and current management
NA Osna, TM Donohue Jr… - Alcohol research: current …, 2017 - ncbi.nlm.nih.gov
Excessive alcohol consumption is a global healthcare problem. The liver sustains the
greatest degree of tissue injury by heavy drinking because it is the primary site of ethanol …
greatest degree of tissue injury by heavy drinking because it is the primary site of ethanol …
Fanconi anaemia and cancer: an intricate relationship
G Nalepa, DW Clapp - Nature Reviews Cancer, 2018 - nature.com
Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
(BMF), developmental abnormalities and predisposition to cancer. Together with other …
[HTML][HTML] Recent advances from basic and clinical studies of esophageal squamous cell carcinoma
S Ohashi, S Miyamoto, O Kikuchi, T Goto, Y Amanuma… - Gastroenterology, 2015 - Elsevier
Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive squamous cell
carcinomas and is highly prevalent in Asia. Alcohol and its metabolite, acetaldehyde, are …
carcinomas and is highly prevalent in Asia. Alcohol and its metabolite, acetaldehyde, are …
Fanconi anemia: current insights regarding epidemiology, cancer, and DNA repair
JD Peake, E Noguchi - Human genetics, 2022 - Springer
Fanconi anemia is a genetic disorder that is characterized by bone marrow failure, as well
as a predisposition to malignancies including leukemia and squamous cell carcinoma …
as a predisposition to malignancies including leukemia and squamous cell carcinoma …
Squamous cell cancers: a unified perspective on biology and genetics
GP Dotto, AK Rustgi - Cancer cell, 2016 - cell.com
Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are
a major cause of cancer mortality. These highly heterogeneous tumors arise from closely …
a major cause of cancer mortality. These highly heterogeneous tumors arise from closely …
Mode of action-based risk assessment of genotoxic carcinogens
A Hartwig, M Arand, B Epe, S Guth, G Jahnke… - Archives of …, 2020 - Springer
The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …
ALDH2 deficiency promotes alcohol-associated liver cancer by activating oncogenic pathways via oxidized DNA-enriched extracellular vesicles
Background & Aims Excessive alcohol consumption is one of the major causes of
hepatocellular carcinoma (HCC). Approximately 30–40% of the Asian population are …
hepatocellular carcinoma (HCC). Approximately 30–40% of the Asian population are …
Metabolic methanol: molecular pathways and physiological roles
YL Dorokhov, AV Shindyapina… - Physiological …, 2015 - journals.physiology.org
Methanol has been historically considered an exogenous product that leads only to
pathological changes in the human body when consumed. However, in normal, healthy …
pathological changes in the human body when consumed. However, in normal, healthy …
Steatotic liver disease: metabolic dysfunction, alcohol, or both?
K Staufer, RE Stauber - Biomedicines, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD), both of
them accounting for fatty liver disease (FLD), are among the most common chronic liver …
them accounting for fatty liver disease (FLD), are among the most common chronic liver …
What is the DNA repair defect underlying Fanconi anemia?
Fanconi anemia (FA) is a rare human genetic disease characterized by bone marrow failure,
cancer predisposition, and genomic instability. It has been known for many years that FA …
cancer predisposition, and genomic instability. It has been known for many years that FA …