Treg cell-based therapies: challenges and perspectives
C Raffin, LT Vo, JA Bluestone - Nature Reviews Immunology, 2020 - nature.com
Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …
Next-generation regulatory T cell therapy
Regulatory T cells (Treg cells) are a small subset of immune cells that are dedicated to
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …
curbing excessive immune activation and maintaining immune homeostasis. Accordingly …
[HTML][HTML] Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop
Summary Foxp3+ T regulatory (Treg) cells promote immunological tumor tolerance, but how
their immune-suppressive function is regulated in the tumor microenvironment (TME) …
their immune-suppressive function is regulated in the tumor microenvironment (TME) …
Regulatory T cells in the treatment of disease
Regulatory T (Treg) cells suppress inflammation and regulate immune system activity. In
patients with systemic or organ-specific autoimmune diseases or those receiving …
patients with systemic or organ-specific autoimmune diseases or those receiving …
Th17 and regulatory T cell balance in autoimmune and inflammatory diseases
M Noack, P Miossec - Autoimmunity reviews, 2014 - Elsevier
This review focuses on the biology of T helper 17 (Th17) and regulatory T (Treg) cells and
their role in inflammatory diseases, such as rheumatoid arthritis. Th17 cells represent a pro …
their role in inflammatory diseases, such as rheumatoid arthritis. Th17 cells represent a pro …
The PD‐1 pathway in tolerance and autoimmunity
LM Francisco, PT Sage, AH Sharpe - Immunological reviews, 2010 - Wiley Online Library
Regulatory T cells (Tregs) and the PD‐1: PD‐ligand (PD‐L) pathway are both critical to
terminating immune responses. Elimination of either can result in the breakdown of …
terminating immune responses. Elimination of either can result in the breakdown of …
Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models
Adoptive transfer of regulatory T cells (Tregs) is therapeutic in type 1 diabetes (T1D) mouse
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …
models. Tregs that are specific for pancreatic islets are more potent than polyclonal Tregs in …
Transcriptional and posttranslational regulation of Th17/Treg balance in health and disease
W Zhang, X Liu, Y Zhu, X Liu, Y Gu… - European Journal of …, 2021 - Wiley Online Library
Regulatory T (Treg) cells and T helper type 17 (Th17) cells play important roles in adaptive
immune responses, antagonizing each other in immune disorders. Th17/Treg balance is …
immune responses, antagonizing each other in immune disorders. Th17/Treg balance is …
Chimeric antigen receptor (CAR) Treg: a promising approach to inducing immunological tolerance
Q Zhang, W Lu, CL Liang, Y Chen, H Liu… - Frontiers in …, 2018 - frontiersin.org
Cellular therapies with polyclonal regulatory T-cells (Tregs) in transplantation and
autoimmune diseases have been carried out in both animal models and clinical trials …
autoimmune diseases have been carried out in both animal models and clinical trials …
CAR/FoxP3-engineered T regulatory cells target the CNS and suppress EAE upon intranasal delivery
M Fransson, E Piras, J Burman, B Nilsson… - Journal of …, 2012 - Springer
Background Multiple sclerosis (MS) is an autoimmune disease of the central nervous system
(CNS). In the murine experimental autoimmune encephalomyelitis (EAE) model of MS, T …
(CNS). In the murine experimental autoimmune encephalomyelitis (EAE) model of MS, T …