One problem area regarding animal models for affective disorders is unclear reproducibility,
including external validity or generalizability. One way to evaluate external validity is with …

Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …

In this study, the impacts of Arginine (Arg) on strawberry fruit quality and postharvest decay
caused by fungi, as well as on the nitric oxide synthase (NOS) pathway of strawberry fruit …

Agmatine, the decarboxylation product of arginine, was largely neglected as an important
player in mammalian metabolism until the mid-1990s, when it was re-discovered as an …

Agmatine, a neurotransmitter/neuromodulator, has shown to exert numerous effects on the
CNS. Chronic stress is a risk factor for development of depression, anxiety and deterioration …

A particular challenge in the development of a bipolar disorder (BD) model in animals is the
complicated clinical course of the condition, characterized by manic, depressive and mixed …

Bipolar disorder (BD) is a chronic mental illness characterized by mood fluctuations that
range from depressive lows to manic highs. Several studies have linked the downregulation …

The ability of the N-methyl-d-aspartate receptor antagonist ketamine to induce a rapid and
sustained antidepressant effect has led to a surge in pre-clinical studies investigating …

Background: Depression is a common and potentially life-threatening mental illness, and
currently, there is a lack of effective treatment. It has been reported that dehydrocorydaline …

Introduction: Present antidepressant treatments are only helpful in a quarter of patients with
bipolar depression, and new strategies are warranted. Increasing evidence suggests that …