Since the completion of the cucumber and panda genome projects using Illumina
sequencing in 2009, the global scientific community has had to pay much more attention to …

Error Correction is important for most next-generation sequencing applications because
highly accurate sequenced reads will likely lead to higher quality results. Many techniques …

Motivation: PacBio single molecule real-time sequencing is a third-generation sequencing
technique producing long reads, with comparatively lower throughput and higher error rate …

Background Next-generation sequencing of cellular RNA (RNA-seq) is rapidly becoming the
cornerstone of transcriptomic analysis. However, sequencing errors in the already short …

Bacteria comprise the most diverse domain of life on Earth, where they occupy nearly every
possible ecological niche and play key roles in biological and chemical processes. Studying …

Characterizing the errors generated by common high-throughput sequencing platforms and
telling true genetic variation from technical artefacts are two interdependent steps, essential …

We introduce Quake, a program to detect and correct errors in DNA sequencing reads.
Using a maximum likelihood approach incorporating quality values and nucleotide specific …

Lighter is a fast, memory-efficient tool for correcting sequencing errors. Lighter avoids
counting k-mers. Instead, it uses a pair of Bloom filters, one holding a sample of the input k …

Motivation: The imperfect sequence data produced by next-generation sequencing
technologies have motivated the development of a number of short-read error correctors in …

Low-cost DNA sequencing technologies have expanded the role for direct nucleic acid
sequencing in the analysis of genomes, transcriptomes, and the metagenomes of whole …