Coronavirus disease 2019 (COVID-19) pneumonia is an evolving disease. We will focus on
the development of its pathophysiologic characteristics over time, and how these time …

Background The mortality of critically ill patients with COVID-19 is high, particularly among
those receiving mechanical ventilation (MV). Despite the high number of patients treated …

Patients with severe lung injury usually have a high respiratory drive, resulting in intense
inspiratory effort that may even worsen lung damage by several mechanisms gathered …

This review summarises the fundamental pathophysiological features of COVID-19 in the
context of the respiratory system. It provides an overview of the key clinical manifestations of …

COVID-19 pneumonia is associated with hypoxaemic respiratory failure, ranging from mild
to severe. Because of the worldwide shortage of ICU beds, a relatively high number of …

Background Some academic organizations recommended that physicians intubate patients
with COVID-19 with a relatively lower threshold of oxygen usage particularly in the early …

Background Patients with COVID-19 acute respiratory distress syndrome (ARDS) have been
shown to have high sedation requirements. Objective The purpose of this study was to …

This tutorial discusses a methodology for causal inference using longitudinal modified
treatment policies. This method facilitates the mathematical formalization, identification, and …

Background The efficacy and safety profiles of prone ventilation among intubated
Coronavirus Disease 2019 (COVID-19) patients remain unclear. The primary objective was …

From the beginning of the pandemic, the diagnosis and management of hypoxemia has
been an essential aspect of coronavirus disease 2019 (COVID-19) care. Within the first 2 …