Targeting apoptosis and autophagy following spinal cord injury: Therapeutic approaches to polyphenols and candidate phytochemicals

F Abbaszadeh, S Fakhri, H Khan - Pharmacological Research, 2020 - Elsevier
Spinal cord injury (SCI) is a neurological disorder associated with the loss of sensory and
motor function. Understanding the precise dysregulated signaling pathways, especially …

The green tea polyphenolic catechin epigallocatechin gallate and neuroprotection

AR Khalatbary, E Khademi - Nutritional neuroscience, 2020 - Taylor & Francis
Epigallocatechin gallate is the most abundant composition of the tea catechins and is
thought to be responsible for the majority of biological activity of green tea extracts such as …

Mechanisms underlying the effects of the green tea polyphenol EGCG in sarcopenia prevention and management

T Wang, H Xu, S Wu, Y Guo, G Zhao… - Journal of Agricultural …, 2023 - ACS Publications
Sarcopenia is prevalent among the older population and severely affects human health. Tea
catechins may benefit for skeletal muscle performance and protect against secondary …

The importance of natural antioxidants in the treatment of spinal cord injury in animal models: an overview

A Coyoy-Salgado, JJ Segura-Uribe… - Oxidative Medicine …, 2019 - Wiley Online Library
Patients with spinal cord injury (SCI) face devastating health, social, and financial
consequences, as well as their families and caregivers. Reducing the levels of reactive …

Ultramicronized palmitoylethanolamide and paracetamol, a new association to relieve hyperalgesia and pain in a sciatic nerve injury model in rat

AF Peritore, R Siracusa, R Fusco… - International Journal of …, 2020 - mdpi.com
Inflammation is known to be an essential trigger of the pathological changes that have a
critical impact on nerve repair and regeneration; moreover, damage to peripheral nerves …

Effect of PEA-OXA on neuropathic pain and functional recovery after sciatic nerve crush

E Gugliandolo, R D'amico, M Cordaro, R Fusco… - Journal of …, 2018 - Springer
Background Animal models of sciatic nerve injury are commonly used to study neuropathic
pain as well as axon regeneration. Inflammation/immune response at the site of nerve lesion …

Catechins enhance skeletal muscle performance

P Li, A Liu, W Xiong, H Lin, W Xiao… - Critical reviews in …, 2020 - Taylor & Francis
Muscle-related disorders, such as sarcopenia and cachexia, caused by aging and chronic
diseases can lead to the loss of muscle mass and strength to different degrees, severely …

[HTML][HTML] A green tea polyphenol epigallocatechin-3-gallate enhances neuroregeneration after spinal cord injury by altering levels of inflammatory cytokines

LM Urdzikova, J Ruzicka, K Karova, A Kloudova… - …, 2017 - Elsevier
Spinal cord injury (SCI) is a debilitating condition which is characterized by an extended
secondary injury due to the presence of inflammatory local milieu. Epigallocatechin gallate …

[HTML][HTML] NGF and PI3K/Akt signaling participate in the ventral motor neuronal protection of curcumin in sciatic nerve injury rat models

Q Sang, D Sun, Z Chen, W Zhao - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Objective It has been reported that sciatic nerve injury (SNI) leads to degeneration, damage,
and apoptosis of motor neurons. Nerve growth factor (NGF) plays a pivotal role in …

Epigallocatechin gallate modulates essential elements, Zn/Cu ratio, hazardous metal, lipid peroxidation, and antioxidant activity in the brain cortex during cerebral …

MC Lin, CC Liu, YC Lin, CW Hsu - Antioxidants, 2022 - mdpi.com
Cerebral ischemia induces oxidative brain injury via increased oxidative stress.
Epigallocatechin gallate (EGCG) exerts anti-oxidant, anti-inflammatory, and metal chelation …