Morpholinos, morpholino upregulating, and associated methods
BK Ambati, H Uehara - US Patent 9,534,222, 2017 - Google Patents
Hou X. Kumar A. Lee C. Wang B, Arjunan P. et al.(2010) PDGF-CC blockade inhibits
pathological angiogenesis by acting on multiple cellular and molecular targets. Proc Natl …
pathological angiogenesis by acting on multiple cellular and molecular targets. Proc Natl …
Formats for organic compounds for use in RNA interference
JL Baryza, M Blommers, W Chutkow… - US Patent …, 2018 - Google Patents
The disclosure relates to compositions comprising a RNAi agent having a novel format
including a spacer subunit. The disclosure relates to compositions comprising a RNAi agent …
including a spacer subunit. The disclosure relates to compositions comprising a RNAi agent …
Organic compositions to treat APOC3-related diseases
J Weiler, W Chutkow, JL Baryza, A Krueger… - US Patent …, 2019 - Google Patents
2017-07-13 Assigned to NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC.
reassignment NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. ASSIGNMENT …
reassignment NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. ASSIGNMENT …
Organic compounds to treat hepatitis B virus
JL Baryza, M Blommers, C Fernandez, E Geno… - US Patent …, 2019 - Google Patents
2018-04-03 Assigned to NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC.
reassignment NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. ASSIGNMENT …
reassignment NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH INC. ASSIGNMENT …
Method of encapsulating a nucleic acid in a lipid nanoparticle host
KA Bowman, N Gardner, T Jeannotte… - US Patent …, 2019 - Google Patents
Encapsulated nucleic acid nanoparticles of uniformly small particle size are produced by
intersecting one or more nucleic acid streams with one or more lipid streams. The …
intersecting one or more nucleic acid streams with one or more lipid streams. The …
Inhibition of PRMT5 to treat MTAP-deficiency-related diseases
KJ Mavrakis, E MCDONALD III, FP Stegmeier - 2016 - Google Patents
WO2016038550A1 - Inhibition of prmt5 to treat mtap-deficiency-related diseases - Google Patents
WO2016038550A1 - Inhibition of prmt5 to treat mtap-deficiency-related diseases - Google Patents …
WO2016038550A1 - Inhibition of prmt5 to treat mtap-deficiency-related diseases - Google Patents …
SiRNA targeting HSR1
EA Nudler, P Bibhusita - US Patent 10,059,944, 2018 - Google Patents
US10059944B2 - SiRNA targeting HSR1 - Google Patents US10059944B2 - SiRNA
targeting HSR1 - Google Patents SiRNA targeting HSR1 Download PDF Info Publication …
targeting HSR1 - Google Patents SiRNA targeting HSR1 Download PDF Info Publication …
Organic compositions to treat EPAS1-related diseases
B Bettencourt, S Ganesh, E George, D Heusken… - US Patent …, 2018 - Google Patents
The present disclosure relates to methods of treating EPAS1-related diseases such as
cancer, metastases, astrocytoma, bladder cancer, breast cancer, chondrosarcoma …
cancer, metastases, astrocytoma, bladder cancer, breast cancer, chondrosarcoma …
Organic compositions to treat APOC3-related diseases
J Weiler, W Chutkow, JL Baryza, A Krueger… - US Patent …, 2021 - Google Patents
The present disclosure relates to compositions and methods for treating APOC3-related
diseases such as: hypertriglyceridemia (eg, Type V Hypertriglyceridemia), abnormal lipid …
diseases such as: hypertriglyceridemia (eg, Type V Hypertriglyceridemia), abnormal lipid …
RNAi agents and compositions for inhibiting expression of apolipoprotein C-III (APOC3)
Z Li, R Zhu, T Pei, S Kanner, S Wong - US Patent 11,214,801, 2022 - Google Patents
0 CC (*) OP ([O-])(OCCCCNC (Cc1cnc (c (CCO) ccc2) c2c1-c1ccccc1)= O)= O Chemical
compound CC (*) OP ([O-])(OCCCCNC (Cc1cnc (c (CCO) ccc2) c2c1-c1ccccc1)= O)= O …
compound CC (*) OP ([O-])(OCCCCNC (Cc1cnc (c (CCO) ccc2) c2c1-c1ccccc1)= O)= O …