Unraveling plant natural chemical diversity for drug discovery purposes

E Lautié, O Russo, P Ducrot, JA Boutin - Frontiers in pharmacology, 2020 - frontiersin.org
The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …

Biodefense in the age of synthetic biology

National Academies of Sciences, Division on Earth… - 2019 - books.google.com
Scientific advances over the past several decades have accelerated the ability to engineer
existing organisms and to potentially create novel ones not found in nature. Synthetic …

An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals

P Carbonell, AJ Jervis, CJ Robinson, C Yan… - Communications …, 2018 - nature.com
The microbial production of fine chemicals provides a promising biosustainable
manufacturing solution that has led to the successful production of a growing catalog of …

Bioprivileged molecules: creating value from biomass

BH Shanks, PL Keeling - Green Chemistry, 2017 - pubs.rsc.org
The petrochemical industry is built on C2–C4 alkenes and aromatics as intermediate
molecules, which are converted to a range of products. This industry is highly developed …

Precise quantification of translation inhibition by mRNA structures that overlap with the ribosomal footprint in N-terminal coding sequences

A Espah Borujeni, D Cetnar, I Farasat… - Nucleic acids …, 2017 - academic.oup.com
A mRNA's translation rate is controlled by several sequence determinants, including the
presence of RNA structures within the N-terminal regions of its coding sequences. However …

Antimicrobial biosynthetic potential and diversity of culturable soil actinobacteria from forest ecosystems of Northeast India

P Sharma, D Thakur - Scientific reports, 2020 - nature.com
Actinobacteria is a goldmine for the discovery of abundant secondary metabolites with
diverse biological activities. This study explores antimicrobial biosynthetic potential and …

Selenzyme: enzyme selection tool for pathway design

P Carbonell, J Wong, N Swainston, E Takano… - …, 2018 - academic.oup.com
Synthetic biology applies the principles of engineering to biology in order to create
biological functionalities not seen before in nature. One of the most exciting applications of …

Automated engineering of synthetic metabolic pathways for efficient biomanufacturing

I Otero-Muras, P Carbonell - Metabolic Engineering, 2021 - Elsevier
Metabolic engineering involves the engineering and optimization of processes from single-
cell to fermentation in order to increase production of valuable chemicals for health, food …

A living foundry for synthetic biological materials: a synthetic biology roadmap to new advanced materials

RA Le Feuvre, NS Scrutton - Synthetic and Systems Biotechnology, 2018 - Elsevier
Society is on the cusp of harnessing recent advances in synthetic biology to discover new
bio-based products and routes to their affordable and sustainable manufacture. This is no …

Directing evolution: the next revolution in drug discovery?

AM Davis, AT Plowright, E Valeur - Nature Reviews Drug Discovery, 2017 - nature.com
The strong biological rationale to pursue challenging drug targets such as protein–protein
interactions has stimulated the development of novel screening strategies, such as DNA …