Unraveling plant natural chemical diversity for drug discovery purposes
E Lautié, O Russo, P Ducrot, JA Boutin - Frontiers in pharmacology, 2020 - frontiersin.org
The screening and testing of extracts against a variety of pharmacological targets in order to
benefit from the immense natural chemical diversity is a concern in many laboratories …
benefit from the immense natural chemical diversity is a concern in many laboratories …
Biodefense in the age of synthetic biology
National Academies of Sciences, Division on Earth… - 2019 - books.google.com
Scientific advances over the past several decades have accelerated the ability to engineer
existing organisms and to potentially create novel ones not found in nature. Synthetic …
existing organisms and to potentially create novel ones not found in nature. Synthetic …
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals
The microbial production of fine chemicals provides a promising biosustainable
manufacturing solution that has led to the successful production of a growing catalog of …
manufacturing solution that has led to the successful production of a growing catalog of …
Bioprivileged molecules: creating value from biomass
BH Shanks, PL Keeling - Green Chemistry, 2017 - pubs.rsc.org
The petrochemical industry is built on C2–C4 alkenes and aromatics as intermediate
molecules, which are converted to a range of products. This industry is highly developed …
molecules, which are converted to a range of products. This industry is highly developed …
Precise quantification of translation inhibition by mRNA structures that overlap with the ribosomal footprint in N-terminal coding sequences
A Espah Borujeni, D Cetnar, I Farasat… - Nucleic acids …, 2017 - academic.oup.com
A mRNA's translation rate is controlled by several sequence determinants, including the
presence of RNA structures within the N-terminal regions of its coding sequences. However …
presence of RNA structures within the N-terminal regions of its coding sequences. However …
Antimicrobial biosynthetic potential and diversity of culturable soil actinobacteria from forest ecosystems of Northeast India
Actinobacteria is a goldmine for the discovery of abundant secondary metabolites with
diverse biological activities. This study explores antimicrobial biosynthetic potential and …
diverse biological activities. This study explores antimicrobial biosynthetic potential and …
Selenzyme: enzyme selection tool for pathway design
Synthetic biology applies the principles of engineering to biology in order to create
biological functionalities not seen before in nature. One of the most exciting applications of …
biological functionalities not seen before in nature. One of the most exciting applications of …
Automated engineering of synthetic metabolic pathways for efficient biomanufacturing
I Otero-Muras, P Carbonell - Metabolic Engineering, 2021 - Elsevier
Metabolic engineering involves the engineering and optimization of processes from single-
cell to fermentation in order to increase production of valuable chemicals for health, food …
cell to fermentation in order to increase production of valuable chemicals for health, food …
A living foundry for synthetic biological materials: a synthetic biology roadmap to new advanced materials
RA Le Feuvre, NS Scrutton - Synthetic and Systems Biotechnology, 2018 - Elsevier
Society is on the cusp of harnessing recent advances in synthetic biology to discover new
bio-based products and routes to their affordable and sustainable manufacture. This is no …
bio-based products and routes to their affordable and sustainable manufacture. This is no …
Directing evolution: the next revolution in drug discovery?
AM Davis, AT Plowright, E Valeur - Nature Reviews Drug Discovery, 2017 - nature.com
The strong biological rationale to pursue challenging drug targets such as protein–protein
interactions has stimulated the development of novel screening strategies, such as DNA …
interactions has stimulated the development of novel screening strategies, such as DNA …