Stress is an important factor that affects physical and mental status of a healthy person
disturbing homeostasis of the body. Changes in the lifestyle are one of the major causes that …

Ovarian aging is a natural and physiological aging process characterized by loss of quantity
and quality of oocyte or follicular pool. As it is generally accepted that women are born with a …

Apoptosis causes elimination of more than 99% of germ cells from cohort of ovary through
follicular atresia. Less than 1% of germ cells, which are culminated in oocytes further …

Various environmental insults including diseases, heat and oxidative stress could lead to
abnormal growth, functions and apoptosis in granulosa cells during ovarian follicle growth …

In vitro maturation (IVM) is emerging as a popular technology at the forefront of fertility
treatment and preservation. However, standard in vitro culture (IVC) conditions usually …

Oocyte developmental competence is one of the determining factors that influence the
outcomes of an IVF cycle regarding the ability of a female gamete to reach maturation, be …

Oocyte maturation disorder and decreased quality are the main causes of infertility in
women, and granulosa cells (GCs) provide the only microenvironment for oocyte maturation …

Calcium (Ca++) is one of the major signal molecules that regulate various aspects of cell
functions including cell cycle progression, arrest, and apoptosis in wide variety of cells. This …

Oxygen deprivation affects human health by modulating system as well as cellular
physiology. Hypoxia generates reactive oxygen species (ROS), causes oxidative stress and …

Mammalian ovary contains millions of germ cells during embryonic life but only few of them
are culminated into oocytes that achieve meiotic competency just prior to ovulation. The …