During cardiac development and morphogenesis, cardiac progenitor cells differentiate into
cardiomyocytes that expand in number and size to generate the fully formed heart. Much is …

Mitochondria are the main site of intracellular synthesis of ATP, which provides energy for
various physiological activities of the cell. Cardiomyocytes have a high density of …

Mammalian cardiomyocytes undergo major maturational changes in preparation for birth
and postnatal life. Immature cardiomyocytes contribute to cardiac growth via proliferation …

Approximately 7 million people are affected by acute myocardial infarction (MI) each year,
and despite significant therapeutic and diagnostic advancements, MI remains a leading …

Cardioimmunology is a field that encompasses the immune cells and pathways that
modulate cardiac function in homeostasis and regulate the temporal balance between tissue …

Cardiovascular disease (CVD) is the biggest killer worldwide, composing a major economic
burden for health care systems. Obesity and diabetes are dual epidemics on the rise and …

Simple Summary Death from injury to the heart from a variety of causes remains a major
cause of mortality worldwide. The cardiomyocyte, the major contracting cell of the heart, is …

Defining the mechanisms that govern heart development is essential for identifying the
etiology of congenital heart disease. Here, quantitative proteomics was used to measure …

The adult heart is made up of cardiomyocytes (CMs) that maintain pump function but are
unable to divide and form new myocytes in response to myocardial injury. In contrast, the …

Abstract miRNAs modulate cardiomyocyte specification by targeting mRNAs of cell cycle
regulators and acting in cardiac muscle lineage gene regulatory loops. It is unknown if or to …