Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

Autophagy is well equipped functionally to isolate microbial pathogens in autophagosomes
and to carry out their clearance by dismemberment in the course of catabolic processes in …

A variety of mechanisms deliver cytosolic materials to the lysosomal compartment for
degradation through autophagy. Here, we focus on two autophagic pathways, the …

This review focuses on chaperone-mediated autophagy (CMA), one of the proteolytic
systems that contributes to degradation of intracellular proteins in lysosomes. CMA substrate …

All cellular proteins undergo continuous synthesis and degradation. This permanent
renewal is necessary to maintain a functional proteome and to allow rapid changes in levels …

The cellular uptake, intracellular processing, and presentation of foreign antigen are crucial
processes for eliciting an effective adaptive host response to the majority of pathogens. The …

(Macro) autophagy is a bulk degradation process that mediates the clearance of long-lived
proteins and organelles. Autophagy is initiated by double-membraned structures, which …

Lysosomes are the primary catabolic compartments of eukaryotic cells. They degrade
extracellular material that has been internalized by endocytosis and intracellular …

Many annotated long noncoding RNAs (lncRNAs) harbor predicted short open reading
frames (sORFs), but the coding capacities of these sORFs and the functions of the resulting …

ABSTRACT LAMP2 (lysosomal associated membrane protein 2) is one of the major protein
components of the lysosomal membrane. There currently exist three LAMP2 isoforms …